Exploiting the differences in reactivity of the hydroxyl groups of glucal allows for rapid access to the sLex tetrasaccharide glycal. This compound is readily converted to the title compounds by azaglycosylation followed by deprotection. The use of stannyl alkoxides in the glycosylation - rearrangement step allows for the use of minimally protected glycosides as the glycosyl acceptors. Employing a galactal epoxide as a glycosyl donor allows for a maximally convergent synthesis of the Lex glycal.
|Original language||English (US)|
|Number of pages||14|
|Journal||Journal of the American Chemical Society|
|State||Published - Feb 22 1995|
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