Appendicular skeletal and visceral malformations induced by thalidomide in bonnet monkeys

Andrew G Hendrickx, Lois Newman

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Twenty‐nine pregnancies were obtained in 21 female bonnet monkeys. The females were housed individually and were mated for a 2‐h period, usually 2 days before midcycle. The day of mating was designated as day o of pregnancy. After pregnancy was confirmed by rectal palpation the animals each received 5, 10, or 30 mg/kg thalidomide orally, either as single doses on days 24, 25, 26, 27, 28, or 29 or once per day on days 25–27 or 41–44. With 5 and 10 mg/kg only malformations of the forelimbs were observed, characterized by total absence (amelia) or partial absence (meromelia) of the free limb. In all cases the malformations were more severe on the left side than the right. No craniocaudal developmental gradient was noted with 10 mg/kg. With 30 mg/kg forelimb and hindlimb malformations occurred, although the hindlimb malformations were mild and consisted essentially of either bowing or partial absence of the femur. A craniocaudal developmental gradient was evident with 30 mg/kg. Treatment during the time of palate closure (days 41–44) did not affect normal palate development. Absence and/or malformations of the uterus, ovaries, kidney, heart, brain, spleen, and umbilical arteries also occurred.

Original languageEnglish (US)
Pages (from-to)151-159
Number of pages9
JournalTeratology
Volume7
Issue number2
DOIs
StatePublished - 1973

Fingerprint

Macaca radiata
Bending (forming)
Thalidomide
Brain
Animals
Forelimb
Palate
Hindlimb
Pregnancy
Ectromelia
Digital Rectal Examination
Umbilical Arteries
Femur
Uterus
Ovary
Spleen
Extremities
Kidney

ASJC Scopus subject areas

  • Embryology
  • Toxicology
  • Developmental Biology
  • Health, Toxicology and Mutagenesis

Cite this

Appendicular skeletal and visceral malformations induced by thalidomide in bonnet monkeys. / Hendrickx, Andrew G; Newman, Lois.

In: Teratology, Vol. 7, No. 2, 1973, p. 151-159.

Research output: Contribution to journalArticle

Hendrickx, Andrew G ; Newman, Lois. / Appendicular skeletal and visceral malformations induced by thalidomide in bonnet monkeys. In: Teratology. 1973 ; Vol. 7, No. 2. pp. 151-159.
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