Apparent outbreaks of Clostridium difficile-associated diarrhea in horses in a veterinary medical teaching hospital.

B. R. Madewell, Y. J. Tang, S. Jang, J. E. Madigan, D. C. Hirsh, P. H. Gumerlock, J. Silva

Research output: Contribution to journalArticle

75 Scopus citations

Abstract

Intestinal colonization with toxigenic strains of Clostridium difficile was documented in 9 of 10 horses with acute onset diarrhea in a veterinary medical teaching hospital, whereas a similar isolate was detected in only 1 of 23 other horses without diarrhea in the hospital. One horse with diarrhea was infected simultaneously with both C. difficile and Salmonella krefeld. Clostridium difficile was detected by fecal culture on selective medium, confirmed with a latex particle agglutination test, and identified as toxigenic by polymerase chain reaction amplification of toxin A and toxin B gene sequences. Using an arbitrarily-primed polymerase chain reaction, 6 distinct C. difficile isolates were detected in the feces of the 9 affected horses at the time of the outbreak of diarrhea.

Original languageEnglish (US)
Pages (from-to)343-346
Number of pages4
JournalJournal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
Volume7
Issue number3
StatePublished - Jul 1995

ASJC Scopus subject areas

  • Microbiology
  • veterinary(all)

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