Apoptosis of gastric lymphocytes in Helicobacter pylori-infected rhesus macaques

Satya Dandekar, Elizabeth Reay, Jennifer M. Taylor, Jay V Solnick

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


In vitro studies suggest that H. pylori induces apoptosis in gastric epithelial cells and perhaps in gastric lymphocytes as well. However, the early effects of H. pylori infection on lymphocyte apoptosis have not been examined in experimental animal models, nor have studies been performed using markers specific for T cells and T-cell subsets. Gastric T-cell apoptosis and Fas ligand expression were examined by flow cytometry after experimental infection of rhesus macaques with H. pylori. Infection induced transient apoptosis of gastric CD4+ and CD8+ T-cells, which began as soon as three days after inoculation and declined to baseline within eight weeks. Fas ligand expression showed a similar transient induction, suggesting that it mediates gastric T-cell apoptosis. We propose that transient, Fas-mediated apoptosis in gastric lymphocytes is a compensatory response to the initial T-cell inflammatory response after acute H. pylori infection.

Original languageEnglish (US)
Pages (from-to)1073-1080
Number of pages8
JournalDigestive Diseases and Sciences
Issue number6
StatePublished - Jun 1 2003


  • Apoptosis
  • Fas
  • Heliocbacter pylori
  • Lymphocyte
  • Rhesus

ASJC Scopus subject areas

  • Gastroenterology


Dive into the research topics of 'Apoptosis of gastric lymphocytes in Helicobacter pylori-infected rhesus macaques'. Together they form a unique fingerprint.

Cite this