Apolipoprotein E Genotypes, Age, Race, and Cognitive Decline in a Population Sample

Kumar Rajan, Lisa L. Barnes, Robert S. Wilson, Jennifer Weuve, Elizabeth A. McAninch, Denis A. Evans

Research output: Contribution to journalArticle

Abstract

OBJECTIVES: To examine the effects of age and race on the association of apolipoprotein E (APOE) genotypes with cognitive decline in a population sample. DESIGN: Longitudinal study of 18 years’ duration. SETTING: Biracial urban US population sample. PARTICIPANTS: There were a total of 5807 participants, 60% African American (AA) and 40% European American (EA). MEASUREMENTS: A composite cognitive function based on individual tests of episodic memory, perceptual speed, and the Mini-Mental State Examination. RESULTS: The frequencies of APOE ε2/ε3 (14% vs 12%), ε2/ε4 (4% vs 2%), ε3/ε4 (29% vs 22%), and ε4/ε4 (4% vs 2%) genotypes were higher among AAs than EAs. After adjusting for demographic factors, the rate of decline in global cognition was twice as high among participants with the APOE ε4/ε4 genotype compared to participants with the APOE ε3/ε3 genotype (0.097 vs 0.048 SD units [SDUs] per year; P <.0001). This doubling was not different between AAs (0.091 vs 0.045 SDUs per year) and EAs (0.118 vs 0.059 SDUs per year) (Pinteraction =.63). The APOE ε3/ε4 genotype was associated with a higher rate of decline with age (Pinteraction =.021), while the APOE ε2/ε4 genotype (Pinteraction =.016) and the APOE ε2/ε3 genotype (Pinteraction =.043) were associated with a lower rate of decline with higher age. The APOE ε2/ε2 genotype was associated with a lower rate of decline in episodic memory, while the APOE ε2/ε4 was associated with a higher rate of decline in episodic memory and perceptual speed. CONCLUSIONS: The association of the APOE genotypes with cognitive decline was not different between AAs and EAs. However, individuals with different APOE genotypes showed a lower or a higher rate of decline with age. J Am Geriatr Soc, 1–7, 2018.

Original languageEnglish (US)
JournalJournal of the American Geriatrics Society
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Apolipoproteins E
Genotype
Apolipoprotein E2
Apolipoprotein E3
Apolipoprotein E4
Population
Episodic Memory
Cognition
Cognitive Dysfunction
Urban Population
African Americans
Longitudinal Studies
Demography

Keywords

  • APOE genotypes
  • cognitive decline
  • minority aging

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Apolipoprotein E Genotypes, Age, Race, and Cognitive Decline in a Population Sample. / Rajan, Kumar; Barnes, Lisa L.; Wilson, Robert S.; Weuve, Jennifer; McAninch, Elizabeth A.; Evans, Denis A.

In: Journal of the American Geriatrics Society, 01.01.2018.

Research output: Contribution to journalArticle

Rajan, Kumar ; Barnes, Lisa L. ; Wilson, Robert S. ; Weuve, Jennifer ; McAninch, Elizabeth A. ; Evans, Denis A. / Apolipoprotein E Genotypes, Age, Race, and Cognitive Decline in a Population Sample. In: Journal of the American Geriatrics Society. 2018.
@article{b3a77c681c27429f85337920617c0fb0,
title = "Apolipoprotein E Genotypes, Age, Race, and Cognitive Decline in a Population Sample",
abstract = "OBJECTIVES: To examine the effects of age and race on the association of apolipoprotein E (APOE) genotypes with cognitive decline in a population sample. DESIGN: Longitudinal study of 18 years’ duration. SETTING: Biracial urban US population sample. PARTICIPANTS: There were a total of 5807 participants, 60{\%} African American (AA) and 40{\%} European American (EA). MEASUREMENTS: A composite cognitive function based on individual tests of episodic memory, perceptual speed, and the Mini-Mental State Examination. RESULTS: The frequencies of APOE ε2/ε3 (14{\%} vs 12{\%}), ε2/ε4 (4{\%} vs 2{\%}), ε3/ε4 (29{\%} vs 22{\%}), and ε4/ε4 (4{\%} vs 2{\%}) genotypes were higher among AAs than EAs. After adjusting for demographic factors, the rate of decline in global cognition was twice as high among participants with the APOE ε4/ε4 genotype compared to participants with the APOE ε3/ε3 genotype (0.097 vs 0.048 SD units [SDUs] per year; P <.0001). This doubling was not different between AAs (0.091 vs 0.045 SDUs per year) and EAs (0.118 vs 0.059 SDUs per year) (Pinteraction =.63). The APOE ε3/ε4 genotype was associated with a higher rate of decline with age (Pinteraction =.021), while the APOE ε2/ε4 genotype (Pinteraction =.016) and the APOE ε2/ε3 genotype (Pinteraction =.043) were associated with a lower rate of decline with higher age. The APOE ε2/ε2 genotype was associated with a lower rate of decline in episodic memory, while the APOE ε2/ε4 was associated with a higher rate of decline in episodic memory and perceptual speed. CONCLUSIONS: The association of the APOE genotypes with cognitive decline was not different between AAs and EAs. However, individuals with different APOE genotypes showed a lower or a higher rate of decline with age. J Am Geriatr Soc, 1–7, 2018.",
keywords = "APOE genotypes, cognitive decline, minority aging",
author = "Kumar Rajan and Barnes, {Lisa L.} and Wilson, {Robert S.} and Jennifer Weuve and McAninch, {Elizabeth A.} and Evans, {Denis A.}",
year = "2018",
month = "1",
day = "1",
doi = "10.1111/jgs.15727",
language = "English (US)",
journal = "Journal of the American Geriatrics Society",
issn = "0002-8614",
publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - Apolipoprotein E Genotypes, Age, Race, and Cognitive Decline in a Population Sample

AU - Rajan, Kumar

AU - Barnes, Lisa L.

AU - Wilson, Robert S.

AU - Weuve, Jennifer

AU - McAninch, Elizabeth A.

AU - Evans, Denis A.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - OBJECTIVES: To examine the effects of age and race on the association of apolipoprotein E (APOE) genotypes with cognitive decline in a population sample. DESIGN: Longitudinal study of 18 years’ duration. SETTING: Biracial urban US population sample. PARTICIPANTS: There were a total of 5807 participants, 60% African American (AA) and 40% European American (EA). MEASUREMENTS: A composite cognitive function based on individual tests of episodic memory, perceptual speed, and the Mini-Mental State Examination. RESULTS: The frequencies of APOE ε2/ε3 (14% vs 12%), ε2/ε4 (4% vs 2%), ε3/ε4 (29% vs 22%), and ε4/ε4 (4% vs 2%) genotypes were higher among AAs than EAs. After adjusting for demographic factors, the rate of decline in global cognition was twice as high among participants with the APOE ε4/ε4 genotype compared to participants with the APOE ε3/ε3 genotype (0.097 vs 0.048 SD units [SDUs] per year; P <.0001). This doubling was not different between AAs (0.091 vs 0.045 SDUs per year) and EAs (0.118 vs 0.059 SDUs per year) (Pinteraction =.63). The APOE ε3/ε4 genotype was associated with a higher rate of decline with age (Pinteraction =.021), while the APOE ε2/ε4 genotype (Pinteraction =.016) and the APOE ε2/ε3 genotype (Pinteraction =.043) were associated with a lower rate of decline with higher age. The APOE ε2/ε2 genotype was associated with a lower rate of decline in episodic memory, while the APOE ε2/ε4 was associated with a higher rate of decline in episodic memory and perceptual speed. CONCLUSIONS: The association of the APOE genotypes with cognitive decline was not different between AAs and EAs. However, individuals with different APOE genotypes showed a lower or a higher rate of decline with age. J Am Geriatr Soc, 1–7, 2018.

AB - OBJECTIVES: To examine the effects of age and race on the association of apolipoprotein E (APOE) genotypes with cognitive decline in a population sample. DESIGN: Longitudinal study of 18 years’ duration. SETTING: Biracial urban US population sample. PARTICIPANTS: There were a total of 5807 participants, 60% African American (AA) and 40% European American (EA). MEASUREMENTS: A composite cognitive function based on individual tests of episodic memory, perceptual speed, and the Mini-Mental State Examination. RESULTS: The frequencies of APOE ε2/ε3 (14% vs 12%), ε2/ε4 (4% vs 2%), ε3/ε4 (29% vs 22%), and ε4/ε4 (4% vs 2%) genotypes were higher among AAs than EAs. After adjusting for demographic factors, the rate of decline in global cognition was twice as high among participants with the APOE ε4/ε4 genotype compared to participants with the APOE ε3/ε3 genotype (0.097 vs 0.048 SD units [SDUs] per year; P <.0001). This doubling was not different between AAs (0.091 vs 0.045 SDUs per year) and EAs (0.118 vs 0.059 SDUs per year) (Pinteraction =.63). The APOE ε3/ε4 genotype was associated with a higher rate of decline with age (Pinteraction =.021), while the APOE ε2/ε4 genotype (Pinteraction =.016) and the APOE ε2/ε3 genotype (Pinteraction =.043) were associated with a lower rate of decline with higher age. The APOE ε2/ε2 genotype was associated with a lower rate of decline in episodic memory, while the APOE ε2/ε4 was associated with a higher rate of decline in episodic memory and perceptual speed. CONCLUSIONS: The association of the APOE genotypes with cognitive decline was not different between AAs and EAs. However, individuals with different APOE genotypes showed a lower or a higher rate of decline with age. J Am Geriatr Soc, 1–7, 2018.

KW - APOE genotypes

KW - cognitive decline

KW - minority aging

UR - http://www.scopus.com/inward/record.url?scp=85059073965&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85059073965&partnerID=8YFLogxK

U2 - 10.1111/jgs.15727

DO - 10.1111/jgs.15727

M3 - Article

JO - Journal of the American Geriatrics Society

JF - Journal of the American Geriatrics Society

SN - 0002-8614

ER -