Apolipoprotein E genotype and hippocampal asymmetry in Alzheimer's disease: A volumetric MRI study

C. Geroldi, M. P. Laakso, Charles DeCarli, A. Beltramello, A. Bianchetti, H. Soininen, M. Trabucchi, G. B. Frisoni

Research output: Contribution to journalArticle

76 Scopus citations

Abstract

Asymmetry of brain structures is common to many species and is even present in utero. Some developmental, pathological, and dementing diseases are associated with alterations in normal anatomical asymmetries. Anatomical asymmetries, however, have been only superficially studied in Alzheimer's disease. Recent evidence indicates that the allele ε4 of the apolipoprotein E (ApoE), a well known risk factor for Alzheimer's disease, might play a part in determining some brain morphological changes both in normal carriers and in patients with Alzheimer's disease. This study evaluated the effect of the ApoE genotype on hippocampal asymmetry in patients with Alzheimer's disease carrying 0, 1, and 2 copies of the allele. Volumetric right-left differences of the hippocampi were computed in 28 right handed patients with Alzheimer's disease (14 -/-, 9 ε4/-, and 5 ε4/4) and 30 controls without detectable cognitive deficit. In controls, the right hippocampus was larger than the left, whereas in patients with Alzheimer's disease this asymmetry was progressively reduced with increasing gene dose of the ε4 allele, and the asymmetry was reversed in the ε4/4 Alzheimer's disease group. The mean right-left volume differences were: 1.2, 0.7, 0.2, and -1.0 in controls, -/-, ε4/-, and ε4/4 patients, respectively (sex adjusted p for trend = 0.017). The data indicate a dose dependent effect of the ApoE ε4 allele on hippocampal volume asymmetry in Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)93-96
Number of pages4
JournalJournal of Neurology Neurosurgery and Psychiatry
Volume68
Issue number1
DOIs
StatePublished - Jan 2000
Externally publishedYes

Keywords

  • Alzheimer's disease
  • ApoE
  • Apolipoprotein E
  • Asymmetry
  • Hippocampus
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Psychiatry and Mental health

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    Geroldi, C., Laakso, M. P., DeCarli, C., Beltramello, A., Bianchetti, A., Soininen, H., Trabucchi, M., & Frisoni, G. B. (2000). Apolipoprotein E genotype and hippocampal asymmetry in Alzheimer's disease: A volumetric MRI study. Journal of Neurology Neurosurgery and Psychiatry, 68(1), 93-96. https://doi.org/10.1136/jnnp.68.1.93