Apolipoprotein E ε4 and incidence of Alzheimer disease in a community population of older persons

Denis A. Evans, Laurel A Beckett, Terry S. Field, Lin Feng, Marilyn S. Albert, David A. Bennett, Benjamin Tycko, Richard Mayeux

Research output: Contribution to journalArticle

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Abstract

Objective.-To examine the relation between apolipoprotein E status and risk of Alzheimer disease (AD) in a defined population and estimate the fraction of incident AD attributable to the ε allele. Design.-.Community- based cohort study. Setting.-East Boston, Mass. Participants.-A random sample of 578 community residents aged 65 years and older free of AD. Main Outcome Measure.-Clinical diagnosis of AD by uniform, structured evaluation. Results.-The increased risk of AD associated with the presence of the ε4 allele was less than that found in most family and case-control studies. Persons with the ε4 or ε3/ε4 genotypes had 2.27 (95% confidence interval, 1.06-4.89) times the risk of incident disease compared with those with the ε/ε3 genotype. The ε4 allele accounted for a fairly small fraction of the incidence of AD; if the allele did not exist or had no effect on disease risk, the incidence would be reduced by only 13.7%. The effect of the ε4 allele on risk of AD did not appear to vary with age. Conclusions.-The apolipoprotein E ε4 allele is an important genetic risk factor for AD but accounts for a fairly small fraction of disease occurrence in this population-based study. Continued efforts to identify other environmental and genetic risk factors are warranted.

Original languageEnglish (US)
Pages (from-to)822-824
Number of pages3
JournalJournal of the American Medical Association
Volume277
Issue number10
StatePublished - Mar 12 1997
Externally publishedYes

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Apolipoprotein E4
Alzheimer Disease
Alleles
Incidence
Population
Genotype
Apolipoproteins E
Case-Control Studies
Cohort Studies
Outcome Assessment (Health Care)
Confidence Intervals

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Evans, D. A., Beckett, L. A., Field, T. S., Feng, L., Albert, M. S., Bennett, D. A., ... Mayeux, R. (1997). Apolipoprotein E ε4 and incidence of Alzheimer disease in a community population of older persons. Journal of the American Medical Association, 277(10), 822-824.

Apolipoprotein E ε4 and incidence of Alzheimer disease in a community population of older persons. / Evans, Denis A.; Beckett, Laurel A; Field, Terry S.; Feng, Lin; Albert, Marilyn S.; Bennett, David A.; Tycko, Benjamin; Mayeux, Richard.

In: Journal of the American Medical Association, Vol. 277, No. 10, 12.03.1997, p. 822-824.

Research output: Contribution to journalArticle

Evans, DA, Beckett, LA, Field, TS, Feng, L, Albert, MS, Bennett, DA, Tycko, B & Mayeux, R 1997, 'Apolipoprotein E ε4 and incidence of Alzheimer disease in a community population of older persons', Journal of the American Medical Association, vol. 277, no. 10, pp. 822-824.
Evans, Denis A. ; Beckett, Laurel A ; Field, Terry S. ; Feng, Lin ; Albert, Marilyn S. ; Bennett, David A. ; Tycko, Benjamin ; Mayeux, Richard. / Apolipoprotein E ε4 and incidence of Alzheimer disease in a community population of older persons. In: Journal of the American Medical Association. 1997 ; Vol. 277, No. 10. pp. 822-824.
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