Apolipoprotein AI levels are increased in part as a consequence of reduced catabolism in nephrotic rats

George Kaysen, Elaine Hoye, Hardin Jones

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Apolipoprotein AI (apo AI) synthesis, measured as the turnover of 125I-labeled apo AI-labeled high-density lipoprotein (HDL), was increased significantly in rats with Heymann nephritis (HN) vs. control Sprague-Dawley (SD) rats. However, fractional apo AI catabolic rate was also significantly less in HN vs. SD. We used 125I-apo AI tyramine cellobiose HDL, a marker retained at the catabolic site, to establish where apo AI catabolism decreased in six HN rats, seven rats with adriamycin (Adria)-induced nephrosis, and six control SD. Total renal apo AI catabolism, plus urinary losses, were the same in all three groups, despite significant urinary apo AI in HN and Adria rats. Apo AI catabolism was reduced in skin in both nephrotic groups, accounting for ∼44% of reduced in apo AI catabolism. Thus a significant fraction of apo AI is catabolized in skin of normal male rats. Reduced apo AI catabolism in skin contributes to increased plasma levels in nephrotic rats.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Renal Fluid and Electrolyte Physiology
Volume268
Issue number3 37-3
StatePublished - Mar 1995

Keywords

  • Kidney
  • Lipoprotein
  • Liver
  • Protein synthesis
  • Proteinuria
  • Skin

ASJC Scopus subject areas

  • Physiology

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