Abstract
Apolipoproteins (apo) E and C-I are components of triglyceride (TG)-rich lipoproteins and impact their metabolism. Functional polymorphisms have been established in apoE but not in apoC-I. We studied the relationship between apoE and apoC-I gene polymorphisms and plasma lipoproteins and coronary artery disease (CAD) in 211 African Americans and 306 Caucasians. In African Americans but not in Caucasians, apoC-I H2-carriers had significantly lower total and LDL cholesterol and apoB levels, and higher glucose, insulin, and HOMA-IR levels compared with H1 homozygotes. Differences across CAD phenotypes were seen for the apoC-I polymorphism. African-American H2-carriers without CAD had significantly lower total cholesterol (P < 0.001), LDL cholesterol (P < 0.001), and apoB (P < 0.001) levels compared with H1 homozygotes, whereas no differences were found across apoC-I genotypes for African Americans with CAD. Among African-American apoC-I H1 homozygotes, subjects with CAD had a profile similar to the metabolic syndrome (i.e., higher triglyceride, glucose, and insulin) compared with subjects without CAD. For African-American H2-carriers, subjects with CAD had a pro-atherogenic lipid pattern (i.e., higher LDL cholesterol and apoB levels), compared with subjects without CAD. ApoC-I genotypes showed an ethnically distinct phenotype relationship with regard to CAD and CAD risk factors.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1472-1478 |
| Number of pages | 7 |
| Journal | Journal of Lipid Research |
| Volume | 50 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 2009 |
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Keywords
- Apolipoprotein C-I
- Apolipoprotein E
- Coronary artery disease
- Ethnicity
- Polymorphism
ASJC Scopus subject areas
- Biochemistry
- Cell Biology
- Endocrinology
Cite this
ApoE and ApoC-I polymorphisms : Association of genotype with cardiovascular disease phenotype in African Americans. / Erdembileg, Anuurad; Yamasaki, Masayuki; Shachter, Neil; Pearson, Thomas A.; Berglund, Lars.
In: Journal of Lipid Research, Vol. 50, No. 7, 07.2009, p. 1472-1478.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - ApoE and ApoC-I polymorphisms
T2 - Association of genotype with cardiovascular disease phenotype in African Americans
AU - Erdembileg, Anuurad
AU - Yamasaki, Masayuki
AU - Shachter, Neil
AU - Pearson, Thomas A.
AU - Berglund, Lars
PY - 2009/7
Y1 - 2009/7
N2 - Apolipoproteins (apo) E and C-I are components of triglyceride (TG)-rich lipoproteins and impact their metabolism. Functional polymorphisms have been established in apoE but not in apoC-I. We studied the relationship between apoE and apoC-I gene polymorphisms and plasma lipoproteins and coronary artery disease (CAD) in 211 African Americans and 306 Caucasians. In African Americans but not in Caucasians, apoC-I H2-carriers had significantly lower total and LDL cholesterol and apoB levels, and higher glucose, insulin, and HOMA-IR levels compared with H1 homozygotes. Differences across CAD phenotypes were seen for the apoC-I polymorphism. African-American H2-carriers without CAD had significantly lower total cholesterol (P < 0.001), LDL cholesterol (P < 0.001), and apoB (P < 0.001) levels compared with H1 homozygotes, whereas no differences were found across apoC-I genotypes for African Americans with CAD. Among African-American apoC-I H1 homozygotes, subjects with CAD had a profile similar to the metabolic syndrome (i.e., higher triglyceride, glucose, and insulin) compared with subjects without CAD. For African-American H2-carriers, subjects with CAD had a pro-atherogenic lipid pattern (i.e., higher LDL cholesterol and apoB levels), compared with subjects without CAD. ApoC-I genotypes showed an ethnically distinct phenotype relationship with regard to CAD and CAD risk factors.
AB - Apolipoproteins (apo) E and C-I are components of triglyceride (TG)-rich lipoproteins and impact their metabolism. Functional polymorphisms have been established in apoE but not in apoC-I. We studied the relationship between apoE and apoC-I gene polymorphisms and plasma lipoproteins and coronary artery disease (CAD) in 211 African Americans and 306 Caucasians. In African Americans but not in Caucasians, apoC-I H2-carriers had significantly lower total and LDL cholesterol and apoB levels, and higher glucose, insulin, and HOMA-IR levels compared with H1 homozygotes. Differences across CAD phenotypes were seen for the apoC-I polymorphism. African-American H2-carriers without CAD had significantly lower total cholesterol (P < 0.001), LDL cholesterol (P < 0.001), and apoB (P < 0.001) levels compared with H1 homozygotes, whereas no differences were found across apoC-I genotypes for African Americans with CAD. Among African-American apoC-I H1 homozygotes, subjects with CAD had a profile similar to the metabolic syndrome (i.e., higher triglyceride, glucose, and insulin) compared with subjects without CAD. For African-American H2-carriers, subjects with CAD had a pro-atherogenic lipid pattern (i.e., higher LDL cholesterol and apoB levels), compared with subjects without CAD. ApoC-I genotypes showed an ethnically distinct phenotype relationship with regard to CAD and CAD risk factors.
KW - Apolipoprotein C-I
KW - Apolipoprotein E
KW - Coronary artery disease
KW - Ethnicity
KW - Polymorphism
UR - http://www.scopus.com/inward/record.url?scp=67650510956&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67650510956&partnerID=8YFLogxK
U2 - 10.1194/jlr.P900012-JLR200
DO - 10.1194/jlr.P900012-JLR200
M3 - Article
C2 - 19252179
AN - SCOPUS:67650510956
VL - 50
SP - 1472
EP - 1478
JO - Journal of Lipid Research
JF - Journal of Lipid Research
SN - 0022-2275
IS - 7
ER -