ApoE and ApoC-I polymorphisms: Association of genotype with cardiovascular disease phenotype in African Americans

Anuurad Erdembileg, Masayuki Yamasaki, Neil Shachter, Thomas A. Pearson, Lars Berglund

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Apolipoproteins (apo) E and C-I are components of triglyceride (TG)-rich lipoproteins and impact their metabolism. Functional polymorphisms have been established in apoE but not in apoC-I. We studied the relationship between apoE and apoC-I gene polymorphisms and plasma lipoproteins and coronary artery disease (CAD) in 211 African Americans and 306 Caucasians. In African Americans but not in Caucasians, apoC-I H2-carriers had significantly lower total and LDL cholesterol and apoB levels, and higher glucose, insulin, and HOMA-IR levels compared with H1 homozygotes. Differences across CAD phenotypes were seen for the apoC-I polymorphism. African-American H2-carriers without CAD had significantly lower total cholesterol (P < 0.001), LDL cholesterol (P < 0.001), and apoB (P < 0.001) levels compared with H1 homozygotes, whereas no differences were found across apoC-I genotypes for African Americans with CAD. Among African-American apoC-I H1 homozygotes, subjects with CAD had a profile similar to the metabolic syndrome (i.e., higher triglyceride, glucose, and insulin) compared with subjects without CAD. For African-American H2-carriers, subjects with CAD had a pro-atherogenic lipid pattern (i.e., higher LDL cholesterol and apoB levels), compared with subjects without CAD. ApoC-I genotypes showed an ethnically distinct phenotype relationship with regard to CAD and CAD risk factors.

Original languageEnglish (US)
Pages (from-to)1472-1478
Number of pages7
JournalJournal of Lipid Research
Volume50
Issue number7
DOIs
StatePublished - Jul 2009

Fingerprint

Apolipoproteins C
Apolipoproteins E
Polymorphism
African Americans
Coronary Artery Disease
Cardiovascular Diseases
Genotype
Phenotype
Homozygote
Apolipoproteins B
LDL Cholesterol
Lipoproteins
Apolipoprotein C-I
Triglycerides
Insulin
Glucose
Metabolism
Genes
Cholesterol

Keywords

  • Apolipoprotein C-I
  • Apolipoprotein E
  • Coronary artery disease
  • Ethnicity
  • Polymorphism

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Endocrinology

Cite this

ApoE and ApoC-I polymorphisms : Association of genotype with cardiovascular disease phenotype in African Americans. / Erdembileg, Anuurad; Yamasaki, Masayuki; Shachter, Neil; Pearson, Thomas A.; Berglund, Lars.

In: Journal of Lipid Research, Vol. 50, No. 7, 07.2009, p. 1472-1478.

Research output: Contribution to journalArticle

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