Apocalypsal versus apocryphal: The role of retroviruses in primary biliary cirrhosis

M. Eric Gershwin, Carlo F Selmi

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

The etiology of primary biliary cirrhosis (PBC), much like that of other autoimmune diseases, remains enigmatic. In the case of PBC, several candidates have been proposed, including bacteria, chemicals, and retroviruses. The support for a retroviral etiology has led to a pilot therapeutical interventional program. However, there is limited objective data which can be used to support such a thesis. Until reproducible and mechanistically sound data can be offered, we suggest that pharmaceutical trials are unrealistic and should be discouraged.

Original languageEnglish (US)
Pages (from-to)2356-2358
Number of pages3
JournalAmerican Journal of Gastroenterology
Volume99
Issue number12
DOIs
StatePublished - Dec 2004

ASJC Scopus subject areas

  • Gastroenterology

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