Aortic valve endocarditis in a dog due to Bartonella clarridgeiae

Bruno B Chomel, K. A. Mac Donald, R. W. Kasten, C. C. Chang, A. C. Wey, Janet E Foley, W. P. Thomas, Mark D Kittleson

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

We report the first documented case of endocarditis associated with Bartonella clarridgeiae in any species. B. clarridgeiae was identified as a possible etiological agent of human cat scratch disease. Infective vegetative valvular aortic endocarditis was diagnosed in a 2.5-year-old male neutered boxer. Historically, the dog had been diagnosed with a systolic murmur at 16 months of age and underwent balloon valvuloplasty for severe valvular aortic stenosis. Six months later, the dog was brought to a veterinary hospital with an acute third-degree atrioventricular block and was diagnosed with infective endocarditis. The dog died of cardiopulmonary arrest prior to pacemaker implantation. Necropsy confirmed severe aortic vegetative endocarditis. Blood culture grew a fastidious, gram-negative organism 8 days after being plated. Phenotypic and genotypic characterization of the isolate, including partial sequencing of the citrate synthase (gltA) and 16S rRNA genes indicated that this organism was B. clarridgeiae. DNA extraction from the deformed aortic valve and the healthy pulmonic valve revealed the presence of B. clarridgeiae DNA only from the diseased valve. No Borrelia burgdorferi or Ehrlichia sp. DNA could be identified. Using indirect immunofluorescence tests, the dog was seropositive for B. clarridgeiae and had antibodies against Ehrlichia phagocytophila but not against Ehrlichia canis, Ehrlichia ewingii, B. burgdorferi, or Coxiella burnetii.

Original languageEnglish (US)
Pages (from-to)3548-3554
Number of pages7
JournalJournal of Clinical Microbiology
Volume39
Issue number10
DOIs
StatePublished - 2001

Fingerprint

Bartonella
Endocarditis
Aortic Valve
Ehrlichia
Dogs
Borrelia burgdorferi
DNA
Ehrlichia canis
Anaplasma phagocytophilum
Cat-Scratch Disease
Coxiella burnetii
Systolic Murmurs
Balloon Valvuloplasty
Animal Hospitals
Citrate (si)-Synthase
Atrioventricular Block
Aortic Valve Stenosis
Indirect Fluorescent Antibody Technique
Heart Arrest
rRNA Genes

ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology

Cite this

Aortic valve endocarditis in a dog due to Bartonella clarridgeiae. / Chomel, Bruno B; Mac Donald, K. A.; Kasten, R. W.; Chang, C. C.; Wey, A. C.; Foley, Janet E; Thomas, W. P.; Kittleson, Mark D.

In: Journal of Clinical Microbiology, Vol. 39, No. 10, 2001, p. 3548-3554.

Research output: Contribution to journalArticle

Chomel, Bruno B ; Mac Donald, K. A. ; Kasten, R. W. ; Chang, C. C. ; Wey, A. C. ; Foley, Janet E ; Thomas, W. P. ; Kittleson, Mark D. / Aortic valve endocarditis in a dog due to Bartonella clarridgeiae. In: Journal of Clinical Microbiology. 2001 ; Vol. 39, No. 10. pp. 3548-3554.
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