AO-OCT for in vivo mouse retinal imaging: Application of adaptive lens in wavefornt sensorless aberration correction

Stefano Bonora, Yifan Jian, Edward N Pugh Jr, Marinko V. Sarunic, Robert Zawadzki

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

We demonstrate Adaptive optics - Optical Coherence Tomography (OCT) with modal sensorless Adaptive Optics correction with the use of novel Adaptive Lens (AL) applied for in-vivo imaging of mouse retinas. The AL can generate low order aberrations: defocus, astigmatism, coma and spherical aberration that were used in an adaptive search algorithm. Accelerated processing of the OCT data with a Graphic Processing Unit (GPU) permitted real time extraction of image projection total intensity for arbitrarily selected retinal depth plane to be optimized. Wavefront sensorless control is a viable option for imaging biological structures for which AOOCT cannot establish a reliable wavefront that could be corrected by wavefront corrector. Image quality improvements offered by adaptive lens with sensorless AO-OCT was evaluated on in vitro samples followed by mouse retina data acquired in vivo.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
PublisherSPIE
Volume8934
ISBN (Print)9780819498472
DOIs
StatePublished - 2013
EventOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVIII - San Francisco, CA, United States
Duration: Feb 3 2014Feb 5 2014

Other

OtherOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVIII
CountryUnited States
CitySan Francisco, CA
Period2/3/142/5/14

    Fingerprint

Keywords

  • Aberration compensation
  • Adaptive optics
  • Imaging system
  • Optical coherence tomography

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Bonora, S., Jian, Y., Pugh Jr, E. N., Sarunic, M. V., & Zawadzki, R. (2013). AO-OCT for in vivo mouse retinal imaging: Application of adaptive lens in wavefornt sensorless aberration correction. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 8934). [89340Q] SPIE. https://doi.org/10.1117/12.2042018