AO-OCT for in vivo mouse retinal imaging: Application of adaptive lens in wavefornt sensorless aberration correction

Stefano Bonora; Yifan Jian; Edward N Pugh Jr; Marinko V. Sarunic; Robert Zawadzki

doi:10.1117/12.2042018

AO-OCT for in vivo mouse retinal imaging: Application of adaptive lens in wavefornt sensorless aberration correction

Stefano Bonora, Yifan Jian, Edward N Pugh Jr, Marinko V. Sarunic, Robert Zawadzki

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations

Abstract

We demonstrate Adaptive optics - Optical Coherence Tomography (OCT) with modal sensorless Adaptive Optics correction with the use of novel Adaptive Lens (AL) applied for in-vivo imaging of mouse retinas. The AL can generate low order aberrations: defocus, astigmatism, coma and spherical aberration that were used in an adaptive search algorithm. Accelerated processing of the OCT data with a Graphic Processing Unit (GPU) permitted real time extraction of image projection total intensity for arbitrarily selected retinal depth plane to be optimized. Wavefront sensorless control is a viable option for imaging biological structures for which AOOCT cannot establish a reliable wavefront that could be corrected by wavefront corrector. Image quality improvements offered by adaptive lens with sensorless AO-OCT was evaluated on in vitro samples followed by mouse retina data acquired in vivo.

Original language	English (US)
Title of host publication	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Publisher	SPIE
Volume	8934
ISBN (Print)	9780819498472
DOIs	https://doi.org/10.1117/12.2042018
State	Published - 2013
Event	Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVIII - San Francisco, CA, United States Duration: Feb 3 2014 → Feb 5 2014

Other

Other	Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVIII
Country	United States
City	San Francisco, CA
Period	2/3/14 → 2/5/14

Keywords

Aberration compensation
Adaptive optics
Imaging system
Optical coherence tomography

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics
Electronic, Optical and Magnetic Materials
Biomaterials
Radiology Nuclear Medicine and imaging

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AO-OCT for in vivo mouse retinal imaging : Application of adaptive lens in wavefornt sensorless aberration correction. / Bonora, Stefano; Jian, Yifan; Pugh Jr, Edward N; Sarunic, Marinko V.; Zawadzki, Robert.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8934 SPIE, 2013. 89340Q.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Bonora, S, Jian, Y, Pugh Jr, EN, Sarunic, MV & Zawadzki, R 2013, AO-OCT for in vivo mouse retinal imaging: Application of adaptive lens in wavefornt sensorless aberration correction. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 8934, 89340Q, SPIE, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVIII, San Francisco, CA, United States, 2/3/14. https://doi.org/10.1117/12.2042018

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abstract = "We demonstrate Adaptive optics - Optical Coherence Tomography (OCT) with modal sensorless Adaptive Optics correction with the use of novel Adaptive Lens (AL) applied for in-vivo imaging of mouse retinas. The AL can generate low order aberrations: defocus, astigmatism, coma and spherical aberration that were used in an adaptive search algorithm. Accelerated processing of the OCT data with a Graphic Processing Unit (GPU) permitted real time extraction of image projection total intensity for arbitrarily selected retinal depth plane to be optimized. Wavefront sensorless control is a viable option for imaging biological structures for which AOOCT cannot establish a reliable wavefront that could be corrected by wavefront corrector. Image quality improvements offered by adaptive lens with sensorless AO-OCT was evaluated on in vitro samples followed by mouse retina data acquired in vivo.",

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