Abstract
We demonstrate Adaptive optics - Optical Coherence Tomography (OCT) with modal sensorless Adaptive Optics correction with the use of novel Adaptive Lens (AL) applied for in-vivo imaging of mouse retinas. The AL can generate low order aberrations: defocus, astigmatism, coma and spherical aberration that were used in an adaptive search algorithm. Accelerated processing of the OCT data with a Graphic Processing Unit (GPU) permitted real time extraction of image projection total intensity for arbitrarily selected retinal depth plane to be optimized. Wavefront sensorless control is a viable option for imaging biological structures for which AOOCT cannot establish a reliable wavefront that could be corrected by wavefront corrector. Image quality improvements offered by adaptive lens with sensorless AO-OCT was evaluated on in vitro samples followed by mouse retina data acquired in vivo.
Original language | English (US) |
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Title of host publication | Progress in Biomedical Optics and Imaging - Proceedings of SPIE |
Publisher | SPIE |
Volume | 8934 |
ISBN (Print) | 9780819498472 |
DOIs | |
State | Published - 2013 |
Event | Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVIII - San Francisco, CA, United States Duration: Feb 3 2014 → Feb 5 2014 |
Other
Other | Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVIII |
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Country | United States |
City | San Francisco, CA |
Period | 2/3/14 → 2/5/14 |
Keywords
- Aberration compensation
- Adaptive optics
- Imaging system
- Optical coherence tomography
ASJC Scopus subject areas
- Atomic and Molecular Physics, and Optics
- Electronic, Optical and Magnetic Materials
- Biomaterials
- Radiology Nuclear Medicine and imaging