Anxiolytics block excessive grooming behavior induced by ACTH1-24 and bombesin

Jacqueline Crawley, T. W. Moody

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Diazepam and meprobamate significantly attenuated the increases in grooming behavior induced by peptides. Significant increases in total grooming frequency over a thirty minute observation period were produced by intraventricular administration of 1 μg ACTH1-24 and by 1 μg bombesin to awake rats. Diazepam 1 mg/kg IP blocked the peptide-induced increases in grooming. Non-sedating doses of diazepam also completely reversed the grooming seen when rats were placed in a novel environment. The functional antagonism between anxiolytics and stress-related peptides supports the concept of interacting brain mechanisms mediating stress and anxiety.

Original languageEnglish (US)
Pages (from-to)399-401
Number of pages3
JournalBrain Research Bulletin
Volume10
Issue number3
DOIs
StatePublished - 1983
Externally publishedYes

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Keywords

  • Adrenocorticotrophic hormones
  • Anxiolytics
  • Bombesin
  • Diazepam Meprobamate
  • Grooming behavior
  • Novel environment

ASJC Scopus subject areas

  • Neuroscience(all)

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