Diazepam and meprobamate significantly attenuated the increases in grooming behavior induced by peptides. Significant increases in total grooming frequency over a thirty minute observation period were produced by intraventricular administration of 1 μg ACTH1-24 and by 1 μg bombesin to awake rats. Diazepam 1 mg/kg IP blocked the peptide-induced increases in grooming. Non-sedating doses of diazepam also completely reversed the grooming seen when rats were placed in a novel environment. The functional antagonism between anxiolytics and stress-related peptides supports the concept of interacting brain mechanisms mediating stress and anxiety.
- Adrenocorticotrophic hormones
- Diazepam Meprobamate
- Grooming behavior
- Novel environment
ASJC Scopus subject areas