Anxiolytic-like properties of fominoben

Jacqueline Crawley, Lisa K. Blumstein, Frank Baldino

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Fominoben, a centrally acting antiussive, has been shown recently to bind to the brain benzodiazepine binding site and to antagonize pentylenetetrazol-induced seizures. The present study reports the ability of fominoben to produce anti-anxiety effects analogous to diazepam in a mouse exploratory model for anxiolytics. This action of fominoben was blocked by Ro15-1788, a benzodiazepine receptor antagonist, implicating a brain benzodiazepine binding site in this anxiolytic action of fominoben.

Original languageEnglish (US)
Pages (from-to)277-281
Number of pages5
JournalEuropean Journal of Pharmacology
Volume97
Issue number3-4
DOIs
StatePublished - Jan 27 1984
Externally publishedYes

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Keywords

  • Anxiety
  • Benzodiazepines
  • Fominoben

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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