Anxiety is related to indices of cortical maturation in typically developing children and adolescents

Erik Newman, Wesley K. Thompson, Hauke Bartsch, Donald J. Hagler, Chi Hua Chen, Timothy T. Brown, Joshua M. Kuperman, Connor McCabe, Yoonho Chung, Ondrej Libiger, Natacha Akshoomoff, Cinnamon S. Bloss, B. J. Casey, Linda Chang, Thomas M. Ernst, Jean A. Frazier, Jeffrey R. Gruen, David N. Kennedy, Sarah S. Murray, Elizabeth R. SowellNicholas Schork, Tal Kenet, Walter E. Kaufmann, Stewart Mostofsky, David G Amaral, Anders M. Dale, Terry L. Jernigan

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Anxiety is a risk factor for many adverse neuropsychiatric and socioeconomic outcomes, and has been linked to functional and structural changes in the ventromedial prefrontal cortex (VMPFC). However, the nature of these differences, as well as how they develop in children and adolescents, remains poorly understood. More effective interventions to minimize the negative consequences of anxiety require better understanding of its neurobiology in children. Recent research suggests that structural imaging studies may benefit from clearly delineating between cortical surface area and thickness when examining these associations, as these distinct cortical phenotypes are influenced by different cellular mechanisms and genetic factors. The present study examined relationships between cortical surface area and thickness of the VMPFC and a self-report measure of anxiety (SCARED-R) in 287 youths aged 7–20 years from the Pediatric Imaging, Neurocognition, and Genetics (PING) study. Age and gender interactions were examined for significant associations in order to test for developmental differences. Cortical surface area and thickness were also examined simultaneously to determine whether they contribute independently to the prediction of anxiety. Anxiety was negatively associated with relative cortical surface area of the VMPFC as well as with global cortical thickness, but these associations diminished with age. The two cortical phenotypes contributed additively to the prediction of anxiety. These findings suggest that higher anxiety in children may be characterized by both delayed expansion of the VMPFC and an altered trajectory of global cortical thinning. Further longitudinal studies will be needed to confirm these findings.

Original languageEnglish (US)
JournalBrain Structure and Function
DOIs
StateAccepted/In press - Jul 17 2015

Fingerprint

Anxiety
Prefrontal Cortex
Phenotype
Neurobiology
Self Report
Longitudinal Studies
Pediatrics
Research

Keywords

  • Anxiety
  • Brain development
  • Cortical surface area
  • Cortical thickness
  • Magnetic resonance imaging
  • Ventromedial prefrontal cortex

ASJC Scopus subject areas

  • Neuroscience(all)
  • Anatomy
  • Histology

Cite this

Newman, E., Thompson, W. K., Bartsch, H., Hagler, D. J., Chen, C. H., Brown, T. T., ... Jernigan, T. L. (Accepted/In press). Anxiety is related to indices of cortical maturation in typically developing children and adolescents. Brain Structure and Function. https://doi.org/10.1007/s00429-015-1085-9

Anxiety is related to indices of cortical maturation in typically developing children and adolescents. / Newman, Erik; Thompson, Wesley K.; Bartsch, Hauke; Hagler, Donald J.; Chen, Chi Hua; Brown, Timothy T.; Kuperman, Joshua M.; McCabe, Connor; Chung, Yoonho; Libiger, Ondrej; Akshoomoff, Natacha; Bloss, Cinnamon S.; Casey, B. J.; Chang, Linda; Ernst, Thomas M.; Frazier, Jean A.; Gruen, Jeffrey R.; Kennedy, David N.; Murray, Sarah S.; Sowell, Elizabeth R.; Schork, Nicholas; Kenet, Tal; Kaufmann, Walter E.; Mostofsky, Stewart; Amaral, David G; Dale, Anders M.; Jernigan, Terry L.

In: Brain Structure and Function, 17.07.2015.

Research output: Contribution to journalArticle

Newman, E, Thompson, WK, Bartsch, H, Hagler, DJ, Chen, CH, Brown, TT, Kuperman, JM, McCabe, C, Chung, Y, Libiger, O, Akshoomoff, N, Bloss, CS, Casey, BJ, Chang, L, Ernst, TM, Frazier, JA, Gruen, JR, Kennedy, DN, Murray, SS, Sowell, ER, Schork, N, Kenet, T, Kaufmann, WE, Mostofsky, S, Amaral, DG, Dale, AM & Jernigan, TL 2015, 'Anxiety is related to indices of cortical maturation in typically developing children and adolescents', Brain Structure and Function. https://doi.org/10.1007/s00429-015-1085-9
Newman, Erik ; Thompson, Wesley K. ; Bartsch, Hauke ; Hagler, Donald J. ; Chen, Chi Hua ; Brown, Timothy T. ; Kuperman, Joshua M. ; McCabe, Connor ; Chung, Yoonho ; Libiger, Ondrej ; Akshoomoff, Natacha ; Bloss, Cinnamon S. ; Casey, B. J. ; Chang, Linda ; Ernst, Thomas M. ; Frazier, Jean A. ; Gruen, Jeffrey R. ; Kennedy, David N. ; Murray, Sarah S. ; Sowell, Elizabeth R. ; Schork, Nicholas ; Kenet, Tal ; Kaufmann, Walter E. ; Mostofsky, Stewart ; Amaral, David G ; Dale, Anders M. ; Jernigan, Terry L. / Anxiety is related to indices of cortical maturation in typically developing children and adolescents. In: Brain Structure and Function. 2015.
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