Antiviral treatment of chronic hepatitis B virus infection. I. Changes in viral markers with interferon combined with adenine arabinoside

G. H. Scullard, Richard B Pollard, J. L. Smith, S. L. Sacks, P. B. Gregory, W. S. Robinson, T. C. Merigan

Research output: Contribution to journalArticle

185 Citations (Scopus)

Abstract

Twenty patients with chronic active hepatitis and 12 patients with chronic persistent hepatitis associated with hepatitis B virus (HBV) infection were treated with human leukocyte interferon or adenine arabinoside alone or in combination. With interferon alone, four of 16 patients showed a permanent disappearance of HBV-associated DNA polymerase (DNAP) activity from serum. Of six patients treated with adenine arabinoside alone, only one patient became permanently DNAP negative. With a regimen of multiple cycles of combined interferon and adenine arabinoside, seven of 16 male patients became permanently DNAP negative. Of 69 patients who met the criteria for admission to the program, spontaneous decreases in DNAP activity without treatment were observed in only 9% during a mean observation period of 10 months. In general, patients with chronic active hepatitis, those who are female, and those with a history of recent steroid therapy responded to the antiviral agents significantly better than did the other patients.

Original languageEnglish (US)
Pages (from-to)772-783
Number of pages12
JournalJournal of Infectious Diseases
Volume143
Issue number6
StatePublished - 1981
Externally publishedYes

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Vidarabine
Chronic Hepatitis B
Virus Diseases
Hepatitis B virus
Interferons
Antiviral Agents
Biomarkers
DNA-Directed DNA Polymerase
Chronic Hepatitis
Therapeutics
Interferon-alpha
Steroids
Observation

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Scullard, G. H., Pollard, R. B., Smith, J. L., Sacks, S. L., Gregory, P. B., Robinson, W. S., & Merigan, T. C. (1981). Antiviral treatment of chronic hepatitis B virus infection. I. Changes in viral markers with interferon combined with adenine arabinoside. Journal of Infectious Diseases, 143(6), 772-783.

Antiviral treatment of chronic hepatitis B virus infection. I. Changes in viral markers with interferon combined with adenine arabinoside. / Scullard, G. H.; Pollard, Richard B; Smith, J. L.; Sacks, S. L.; Gregory, P. B.; Robinson, W. S.; Merigan, T. C.

In: Journal of Infectious Diseases, Vol. 143, No. 6, 1981, p. 772-783.

Research output: Contribution to journalArticle

Scullard, G. H. ; Pollard, Richard B ; Smith, J. L. ; Sacks, S. L. ; Gregory, P. B. ; Robinson, W. S. ; Merigan, T. C. / Antiviral treatment of chronic hepatitis B virus infection. I. Changes in viral markers with interferon combined with adenine arabinoside. In: Journal of Infectious Diseases. 1981 ; Vol. 143, No. 6. pp. 772-783.
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