Abstract
Antiviral responses of bovine fetuses to bluetongue virus (BTV) infection were determined. Fetuses inoculated with BTV at 125 days of gestation apparently had cleared all virus by the time of birth; however, the mechanism responsible for virus clearance was not determined. Interferon production and virus clearance were temporally unrelated. Cell-mediated responses to BTV antigens were not detected by the lymphocyte stimulation test using lymphocytes from infected fetuses or cows. Although virus clearance and fetal production of high titers of neutralizing antibody did coincide, it was considered unlikely that antibody alone was responsible for virus clearance. As congenital BTV infection did not lead to specific immunologic tolerance or postnatal persistance of virus, such animals would not be expected to have a major role in the dissemination of BTV.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1469-1473 |
| Number of pages | 5 |
| Journal | American Journal of Veterinary Research |
| Volume | 45 |
| Issue number | 7 |
| State | Published - Jul 1984 |
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- veterinary(all)
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Antiviral responses of bluetongue virus-inoculated bovine fetuses and their dams. / MacLachlan, N. J.; Schore, C. E.; Osburn, B. I.
In: American Journal of Veterinary Research, Vol. 45, No. 7, 07.1984, p. 1469-1473.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Antiviral responses of bluetongue virus-inoculated bovine fetuses and their dams.
AU - MacLachlan, N. J.
AU - Schore, C. E.
AU - Osburn, B. I.
PY - 1984/7
Y1 - 1984/7
N2 - Antiviral responses of bovine fetuses to bluetongue virus (BTV) infection were determined. Fetuses inoculated with BTV at 125 days of gestation apparently had cleared all virus by the time of birth; however, the mechanism responsible for virus clearance was not determined. Interferon production and virus clearance were temporally unrelated. Cell-mediated responses to BTV antigens were not detected by the lymphocyte stimulation test using lymphocytes from infected fetuses or cows. Although virus clearance and fetal production of high titers of neutralizing antibody did coincide, it was considered unlikely that antibody alone was responsible for virus clearance. As congenital BTV infection did not lead to specific immunologic tolerance or postnatal persistance of virus, such animals would not be expected to have a major role in the dissemination of BTV.
AB - Antiviral responses of bovine fetuses to bluetongue virus (BTV) infection were determined. Fetuses inoculated with BTV at 125 days of gestation apparently had cleared all virus by the time of birth; however, the mechanism responsible for virus clearance was not determined. Interferon production and virus clearance were temporally unrelated. Cell-mediated responses to BTV antigens were not detected by the lymphocyte stimulation test using lymphocytes from infected fetuses or cows. Although virus clearance and fetal production of high titers of neutralizing antibody did coincide, it was considered unlikely that antibody alone was responsible for virus clearance. As congenital BTV infection did not lead to specific immunologic tolerance or postnatal persistance of virus, such animals would not be expected to have a major role in the dissemination of BTV.
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UR - http://www.scopus.com/inward/citedby.url?scp=0001291884&partnerID=8YFLogxK
M3 - Article
C2 - 24049920
AN - SCOPUS:0001291884
VL - 45
SP - 1469
EP - 1473
JO - American Journal of Veterinary Research
JF - American Journal of Veterinary Research
SN - 0002-9645
IS - 7
ER -