Antiviral CD8 T cells in the control of primary human cytomegalovirus infection in early childhood

Sharon F. Chen, Wen Wei Tu, Margaret A. Sharp, Eileen Cordoba Tongson, Xiaosong He, Harry B. Greenberg, Tyson H. Holmes, Zhaoti Wang, George Kemble, Anne Marie Manganello, Stuart P. Adler, Cornelia L. Dekker, David B. Lewis, Ann M. Arvin

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Human cytomegalovirus (CMV) establishes persistent infection, with control of replication thought to be mediated by CMV-specific CD8 T cells. Primary CMV infection commonly affects young children and causes prolonged viral shedding in saliva and urine. We investigated whether this virus-host interaction pattern reflects a developmental deficiency of antiviral CD8 T cell-mediated immunity during childhood. CMV-specific CD8 T cell responses in asymptomatic children with active infection were not different from adults with recent or long-term infection in frequency and functional analyses. High urine CMV concentrations were detected, despite these CMV-specific CD8 T cell responses. We conclude that delayed resolution of primary CMV infection in young children is not caused by a deficient CMV-specific CD8 T cell response. Because these healthy children continue to have local CMV replication, we suggest that CD8 T cells may function primarily to prevent symptomatic, disseminated disease.

Original languageEnglish (US)
Pages (from-to)1619-1627
Number of pages9
JournalJournal of Infectious Diseases
Volume189
Issue number9
DOIs
StatePublished - May 1 2004
Externally publishedYes

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Cytomegalovirus Infections
Cytomegalovirus
Antiviral Agents
T-Lymphocytes
Urine
Virus Shedding
Infection Control
Infection
Saliva
Cellular Immunity
Viruses

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Chen, S. F., Tu, W. W., Sharp, M. A., Tongson, E. C., He, X., Greenberg, H. B., ... Arvin, A. M. (2004). Antiviral CD8 T cells in the control of primary human cytomegalovirus infection in early childhood. Journal of Infectious Diseases, 189(9), 1619-1627. https://doi.org/10.1086/383249

Antiviral CD8 T cells in the control of primary human cytomegalovirus infection in early childhood. / Chen, Sharon F.; Tu, Wen Wei; Sharp, Margaret A.; Tongson, Eileen Cordoba; He, Xiaosong; Greenberg, Harry B.; Holmes, Tyson H.; Wang, Zhaoti; Kemble, George; Manganello, Anne Marie; Adler, Stuart P.; Dekker, Cornelia L.; Lewis, David B.; Arvin, Ann M.

In: Journal of Infectious Diseases, Vol. 189, No. 9, 01.05.2004, p. 1619-1627.

Research output: Contribution to journalArticle

Chen, SF, Tu, WW, Sharp, MA, Tongson, EC, He, X, Greenberg, HB, Holmes, TH, Wang, Z, Kemble, G, Manganello, AM, Adler, SP, Dekker, CL, Lewis, DB & Arvin, AM 2004, 'Antiviral CD8 T cells in the control of primary human cytomegalovirus infection in early childhood', Journal of Infectious Diseases, vol. 189, no. 9, pp. 1619-1627. https://doi.org/10.1086/383249
Chen, Sharon F. ; Tu, Wen Wei ; Sharp, Margaret A. ; Tongson, Eileen Cordoba ; He, Xiaosong ; Greenberg, Harry B. ; Holmes, Tyson H. ; Wang, Zhaoti ; Kemble, George ; Manganello, Anne Marie ; Adler, Stuart P. ; Dekker, Cornelia L. ; Lewis, David B. ; Arvin, Ann M. / Antiviral CD8 T cells in the control of primary human cytomegalovirus infection in early childhood. In: Journal of Infectious Diseases. 2004 ; Vol. 189, No. 9. pp. 1619-1627.
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