Antiviral antibodies are necessary for control of simian immunodeficiency virus replication

Chris J Miller, Meritxell Genescà, Kristina Abel, David Montefiori, Donald Forthal, Kristen Bost, Jun Li, David Favre, Joseph M. McCune

Research output: Contribution to journalArticle

59 Scopus citations

Abstract

To better define the role of B cells in the control of pathogenic simian immunodeficiency virus (SIV) replication, six rhesns monkeys were depleted of B cells by intravenous infusion of rifaximato (anti-CD20) 28 days and 7 days before intravaginal SFVmac239 inoculation and every 21 days thereafter until AIDS developed. Although the blood and tissues were similarly depleted of B cells, anti-SIV immunoglobulin G (IgG) antibody responses were completely blocked in only three of the six animals. In all six animals, levels of viral RNA (vRNA) in plasma peaked at 2 weeks and declined by 4 weeks postinoculation (PI). However, the three animals prevented from making an anti-SIV antibody response had significantly higher plasma vRNA levels through 12 weeks PI (P = 0.012). The remaining three B-cell-depleted animals made moderate anti-SIV IgG antibody responses, maintained moderate plasma SIV loads, and showed an expected rate of disease progression, surviving to 24 weeks PI without developing AIDS. In contrast, all three of the B-cell-depleted animals prevented from making anti-SIV IgG responses developed AIDS by 16 weeks PI (P = 0.0001). These observations indicate that antiviral antibody responses are critical in maintaining effective control of SIV replication at early time points postinfection.

Original languageEnglish (US)
Pages (from-to)5024-5035
Number of pages12
JournalJournal of Virology
Volume81
Issue number10
DOIs
StatePublished - May 2007

ASJC Scopus subject areas

  • Immunology

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    Miller, C. J., Genescà, M., Abel, K., Montefiori, D., Forthal, D., Bost, K., Li, J., Favre, D., & McCune, J. M. (2007). Antiviral antibodies are necessary for control of simian immunodeficiency virus replication. Journal of Virology, 81(10), 5024-5035. https://doi.org/10.1128/JVI.02444-06