Antitumor activity of tributyrin in murine melanoma model

Adam Giermasz, Dominika Nowis, Ahmad Jalili, Grzegorz Basak, Maria Marczak, Marcin Makowski, Anna Czajka, Izabela Mlynarczuk, Grayna Hoser, Tomasz Stok osa, Sebastian Lewandowski, Marek Jakóbisiak

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Butyric acid has been known to inhibit growth and to induce differentiation of a variety of tumor cells. Butyrate-treated tumor cells have also been observed to undergo apoptosis. Although butyrate compounds have demonstrated antitumor activity in murine tumor models and have already been admitted to clinical trials in tumor patients, the exact mechanism of their antitumor effects has not been elucidated. The results of our study showed antitumor activity of tributyrin, a butyric acid prodrug, in murine melanoma model and are strongly suggestive that antiangiogenic effects could participate in antitumor effects of butyrate compounds in vivo.

Original languageEnglish (US)
Pages (from-to)143-148
Number of pages6
JournalCancer Letters
Volume164
Issue number2
DOIs
StatePublished - Mar 26 2001
Externally publishedYes

Keywords

  • Butyrate
  • Melanoma
  • Mouse
  • Tributyrin
  • Tumor therapy

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

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