Antisera to bovine oligodendroglia raised in guinea pigs bind to surface of rat oligodendroglia and Schwann cells

R. P. Lisak, Rebecca M. Pruss, P. G E Kennedy, Oded Abramsky, David E Pleasure, D. H. Silberberg

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Antisera against bulk isolated bovine oligodendrocytes was raised in 2 guinea pigs (GPaBO). The sera bound only to surface of rat oligodendrocytes in dissociated rat corpus callosum and cerebellar cultures and only to surface of Schwann cells in primary and secondary sciatic nerve and dorsal root ganglia cultures as determined by indirect immunofluorescence. No cells in muscle or retinal cultures bound the guinea pig antisera. The shared antigen does not seem to be either galactocerebroside (GalC) or a myelin basic protein. GPaBO can serve as a useful marker in double-label experiments to identify oligodendrocytes and Schwann cells in dissociated cultures.

Original languageEnglish (US)
Pages (from-to)119-124
Number of pages6
JournalNeuroscience Letters
Volume17
Issue number1-2
DOIs
StatePublished - 1980
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Antisera to bovine oligodendroglia raised in guinea pigs bind to surface of rat oligodendroglia and Schwann cells'. Together they form a unique fingerprint.

  • Cite this