Antisecretory medication is associated with decreased Helicobacter pylori detection in gastric marginal zone lymphoma

Kurt B. Schaberg, Mark F. Evans, Rebecca Wilcox, Michael R. Lewis

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Helicobacter pylori status influences the prognosis and management of gastric extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma), so accurate determination of H pylori status is of clinical importance. The low rate of histologic H pylori positivity among gastric MALT lymphoma cases at our institution prompted investigation for possible causes. A case series of 24 patients as having gastric MALT lymphoma (with no diffuse large B-cell component) in a tertiary care setting between 1997 and 2010 was identified, and clinical records were reviewed. Immunohistochemical staining for H pylori and BCL10 was performed. This study received institutional review board approval (protocol number M13-033). Thirty-nine percent of cases (9/23) were H pylori positive by histology, and 4 additional patients had positive serologic results; overall, 57% of cases (13/23) were positive for H pylori. Treatment with antisecretory medications was associated with a lower likelihood of histologic positivity (13% among treated patients vs 75% among untreated; P =.04). Nuclear localization of BCL10 was seen in 2 cases and was not associated with H pylori status. Antisecretory medications decrease the likelihood of histologic detection of H pylori in gastric MALT lymphoma cases. Incorporation of results of serologic or other testing is needed to ensure correct classification with respect to H pylori status.

Original languageEnglish (US)
Pages (from-to)397-402
Number of pages6
JournalAnnals of Diagnostic Pathology
Issue number6
StatePublished - Dec 1 2015
Externally publishedYes


  • Antisecretory medication
  • Gastric marginal zone lymphoma
  • Helicobacter pylori
  • Mucosa-associated lymphoid tissue

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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