Antiretroviral penetration across three preclinical animal models and humans in eight putative HIV viral reservoirs

Aaron S. Devanathan, Jason R. Pirone, Ramesh Akkina, Leila Remling-Mulder, Paul Luciw, Lourdes Adamson, J. Victor Garcia, Martina Kovarova, Nicole R. White, Amanda P. Schauer, Kimberly Blake, Craig Sykes, Erin M. Burgunder, Nithya Srinivas, Elias P. Rosen, Angela D.M. Kashuba

Research output: Contribution to journalArticle

Abstract

For HIV cure strategies like “kick and kill” to succeed, antiretroviral (ARV) drugs must reach effective concentrations in putative viral reservoirs. We characterize penetration of six ARVs in three preclinical animal models and humans. We found that standard dosing strategies in preclinical species closely mimicked tissue concentrations in humans for some, but not all, ARVs. These results have implications for interpreting HIV treatment, prevention, or cure interventions between preclinical and clinical models.

Original languageEnglish (US)
Article numbere01639-19
JournalAntimicrobial Agents and Chemotherapy
Volume64
Issue number1
DOIs
StatePublished - Jan 1 2020

Keywords

  • Antiretrovirals
  • HIV
  • Pharmacokinetics
  • Species differences
  • Tissue reservoirs

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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  • Cite this

    Devanathan, A. S., Pirone, J. R., Akkina, R., Remling-Mulder, L., Luciw, P., Adamson, L., Victor Garcia, J., Kovarova, M., White, N. R., Schauer, A. P., Blake, K., Sykes, C., Burgunder, E. M., Srinivas, N., Rosen, E. P., & Kashuba, A. D. M. (2020). Antiretroviral penetration across three preclinical animal models and humans in eight putative HIV viral reservoirs. Antimicrobial Agents and Chemotherapy, 64(1), [e01639-19]. https://doi.org/10.1128/AAC.01639-19