Antioxidant properties of whole body periodic acceleration (pGz)

Arkady Uryash, Jorge Bassuk, Paul Kurlansky, Francisco Altamirano, Jose R. Lopez, Jose A. Adams

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The recognition that oxidative stress is a major component of several chronic diseases has engendered numerous trials of antioxidant therapies with minimal or no direct benefits. Nanomolar quantities of nitric oxide released into the circulation by pharmacologic stimulation of eNOS have antioxidant properties but physiologic stimulation as through increased pulsatile shear stress of the endothelium has not been assessed. The present study utilized a non-invasive technology, periodic acceleration (pGz) that increases pulsatile shear stress such that upregulation of cardiac eNOS occurs, We assessed its efficacy in normal mice and mouse models with high levels of oxidative stress, e.g. Diabetes type 1 and mdx (Duchene Muscular Dystrophy). pGz increased protein expression and upregulated eNOS in hearts. Application of pGz was associated with significantly increased expression of endogenous antioxidants (Glutathioneperoxidase-1(GPX-1), Catalase (CAT), Superoxide, Superoxide Dismutase 1(SOD1). This led to an increase of total cardiac antioxidant capacity along with an increase in the antioxidant response element transcription factor Nrf2 translocation to the nucleus. pGz decreased reactive oxygen species in both mice models of oxidative stress. Thus, pGz is a novel non-pharmacologic method to harness endogenous antioxidant capacity.

Original languageEnglish (US)
Article numbere0131392
JournalPLoS One
Volume10
Issue number7
DOIs
StatePublished - Jul 2 2015

Fingerprint

Antioxidants
Oxidative stress
antioxidants
Oxidative Stress
oxidative stress
Shear stress
shear stress
Antioxidant Response Elements
animal models
Muscular Dystrophies
harness
Medical problems
muscular dystrophy
Type 1 Diabetes Mellitus
insulin-dependent diabetes mellitus
Superoxides
response elements
Catalase
Superoxide Dismutase
Endothelium

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Uryash, A., Bassuk, J., Kurlansky, P., Altamirano, F., Lopez, J. R., & Adams, J. A. (2015). Antioxidant properties of whole body periodic acceleration (pGz). PLoS One, 10(7), [e0131392]. https://doi.org/10.1371/journal.pone.0131392

Antioxidant properties of whole body periodic acceleration (pGz). / Uryash, Arkady; Bassuk, Jorge; Kurlansky, Paul; Altamirano, Francisco; Lopez, Jose R.; Adams, Jose A.

In: PLoS One, Vol. 10, No. 7, e0131392, 02.07.2015.

Research output: Contribution to journalArticle

Uryash, A, Bassuk, J, Kurlansky, P, Altamirano, F, Lopez, JR & Adams, JA 2015, 'Antioxidant properties of whole body periodic acceleration (pGz)', PLoS One, vol. 10, no. 7, e0131392. https://doi.org/10.1371/journal.pone.0131392
Uryash A, Bassuk J, Kurlansky P, Altamirano F, Lopez JR, Adams JA. Antioxidant properties of whole body periodic acceleration (pGz). PLoS One. 2015 Jul 2;10(7). e0131392. https://doi.org/10.1371/journal.pone.0131392
Uryash, Arkady ; Bassuk, Jorge ; Kurlansky, Paul ; Altamirano, Francisco ; Lopez, Jose R. ; Adams, Jose A. / Antioxidant properties of whole body periodic acceleration (pGz). In: PLoS One. 2015 ; Vol. 10, No. 7.
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