Antinociceptive effects of nalbuphine hydrochloride in Hispaniolan Amazon parrots (Amazona ventralis)

David Guzman, Butch Kukanich, Nicholas S. Keuler, Julia M. Klauer, Joanne R Paul-Murphy

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Objective-To evaluate the antinociceptive effects and duration of action of nalbuphine HCl administered IM on thermal thresholds in Hispaniolan Amazon parrots (Amazona ventralis).Animals-14 healthy adult Hispaniolan Amazon parrots of unknown sex.Procedures-3 doses of nalbuphine (12.5, 25, and 50 mg/kg, IM) and saline (0.9% NaCl) solution (control treatment) were evaluated in a blinded complete crossover experimental design by use of foot withdrawal threshold to a noxious thermal stimulus. Baseline data on thermal threshold were generated 1 hour before administration of nalbuphine or saline solution; thermal threshold measurements were obtained 0.5, 1.5, 3, and 6 hours after administration. Results-Nalbuphine administered IM at 12.5 mg/kg significantly increased the thermal threshold (mean change, 2.4oC), compared with results for the control treatment, and significantly changed thermal threshold for up to 3 hours, compared with baseline results (mean change, 2.6o to 3.8oC). Higher doses of nalbuphine did not significantly change thermal thresholds, compared with results for the control treatment, but had a significant effect, compared with baseline results, for up to 3 and 1.5 hours after administration, respectively. Conclusions and Clinical Relevance-Nalbuphine administered IM at 12.5 mg/kg significantly increased the foot withdrawal threshold to a thermal noxious stimulus in Hispaniolan Amazon parrots. Higher doses of nalbuphine did not result in significantly increased thermal thresholds or a longer duration of action and would be expected to result in less analgesic effect than lower doses. Further studies are needed to fully evaluate the analgesic effects of nalbuphine in psittacine species.

Original languageEnglish (US)
Pages (from-to)736-740
Number of pages5
JournalAmerican Journal of Veterinary Research
Volume72
Issue number6
DOIs
StatePublished - Jun 2011

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Nalbuphine
Amazona
analgesic effect
parrots
Hot Temperature
heat
dosage
sodium chloride
Analgesics
Foot
Psittaciformes
duration
Sodium Chloride
Cross-Over Studies
Research Design
Therapeutics
experimental design

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Antinociceptive effects of nalbuphine hydrochloride in Hispaniolan Amazon parrots (Amazona ventralis). / Guzman, David; Kukanich, Butch; Keuler, Nicholas S.; Klauer, Julia M.; Paul-Murphy, Joanne R.

In: American Journal of Veterinary Research, Vol. 72, No. 6, 06.2011, p. 736-740.

Research output: Contribution to journalArticle

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abstract = "Objective-To evaluate the antinociceptive effects and duration of action of nalbuphine HCl administered IM on thermal thresholds in Hispaniolan Amazon parrots (Amazona ventralis).Animals-14 healthy adult Hispaniolan Amazon parrots of unknown sex.Procedures-3 doses of nalbuphine (12.5, 25, and 50 mg/kg, IM) and saline (0.9{\%} NaCl) solution (control treatment) were evaluated in a blinded complete crossover experimental design by use of foot withdrawal threshold to a noxious thermal stimulus. Baseline data on thermal threshold were generated 1 hour before administration of nalbuphine or saline solution; thermal threshold measurements were obtained 0.5, 1.5, 3, and 6 hours after administration. Results-Nalbuphine administered IM at 12.5 mg/kg significantly increased the thermal threshold (mean change, 2.4oC), compared with results for the control treatment, and significantly changed thermal threshold for up to 3 hours, compared with baseline results (mean change, 2.6o to 3.8oC). Higher doses of nalbuphine did not significantly change thermal thresholds, compared with results for the control treatment, but had a significant effect, compared with baseline results, for up to 3 and 1.5 hours after administration, respectively. Conclusions and Clinical Relevance-Nalbuphine administered IM at 12.5 mg/kg significantly increased the foot withdrawal threshold to a thermal noxious stimulus in Hispaniolan Amazon parrots. Higher doses of nalbuphine did not result in significantly increased thermal thresholds or a longer duration of action and would be expected to result in less analgesic effect than lower doses. Further studies are needed to fully evaluate the analgesic effects of nalbuphine in psittacine species.",
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AB - Objective-To evaluate the antinociceptive effects and duration of action of nalbuphine HCl administered IM on thermal thresholds in Hispaniolan Amazon parrots (Amazona ventralis).Animals-14 healthy adult Hispaniolan Amazon parrots of unknown sex.Procedures-3 doses of nalbuphine (12.5, 25, and 50 mg/kg, IM) and saline (0.9% NaCl) solution (control treatment) were evaluated in a blinded complete crossover experimental design by use of foot withdrawal threshold to a noxious thermal stimulus. Baseline data on thermal threshold were generated 1 hour before administration of nalbuphine or saline solution; thermal threshold measurements were obtained 0.5, 1.5, 3, and 6 hours after administration. Results-Nalbuphine administered IM at 12.5 mg/kg significantly increased the thermal threshold (mean change, 2.4oC), compared with results for the control treatment, and significantly changed thermal threshold for up to 3 hours, compared with baseline results (mean change, 2.6o to 3.8oC). Higher doses of nalbuphine did not significantly change thermal thresholds, compared with results for the control treatment, but had a significant effect, compared with baseline results, for up to 3 and 1.5 hours after administration, respectively. Conclusions and Clinical Relevance-Nalbuphine administered IM at 12.5 mg/kg significantly increased the foot withdrawal threshold to a thermal noxious stimulus in Hispaniolan Amazon parrots. Higher doses of nalbuphine did not result in significantly increased thermal thresholds or a longer duration of action and would be expected to result in less analgesic effect than lower doses. Further studies are needed to fully evaluate the analgesic effects of nalbuphine in psittacine species.

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