Antinociception vs motor effects of intrathecal vasopressin as measured by four pain tests

C. L. Thurston; E. S. Culhane; S. N. Suberg; Earl Carstens; L. R. Watkins

doi:10.1016/0006-8993(88)90520-3

Antinociception vs motor effects of intrathecal vasopressin as measured by four pain tests

C. L. Thurston, E. S. Culhane, S. N. Suberg, Earl Carstens, L. R. Watkins

Anesthesiology and Pain Medicine

Research output: Contribution to journal › Article

33 Scopus citations

Abstract

The effects of intrathecal (i.t.) vasopressin (VP) on nociception were quantitatively tested in rats using 4 pain tests: tail flick, tail shock vocalization, hot plate, and formalin. In addition, motor effects of VP were examined qualitatively. I.t. VP produced a prolonged antinociception lasting at least 40 min on the tail flick (2.5 and 25 ng) and formalin (25 ng) tests, and a brief antinociception lasting less than 20 min on the tail shock (25 ng) and hot plate (25 ng) tests. Those rats not responding to the pain tests showed no signs of perceiving the pain stimulus, such as orientation to the stimulus or vocalization. In addition, i.t. VP produced scratching bouts (2.5 and 25 ng) and suppressed hindbody motor function (25 ng). The motor inhibitory effects of VP, although severe in some rats, were brief, lasting less than 15 min. In conclusion, i.t. VP produces antinociception in addition to its motor effects, and these properties appear to be due to separate mechanisms.

Original language	English (US)
Pages (from-to)	1-11
Number of pages	11
Journal	Brain Research
Volume	463
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(88)90520-3
State	Published - Oct 25 1988

Keywords

Analgesia
Motor suppresion
Neuropeptide
Pain
Vasopressin

ASJC Scopus subject areas

Developmental Biology
Molecular Biology
Clinical Neurology
Neuroscience(all)

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Thurston, C. L., Culhane, E. S., Suberg, S. N., Carstens, E., & Watkins, L. R. (1988). Antinociception vs motor effects of intrathecal vasopressin as measured by four pain tests. Brain Research, 463(1), 1-11. https://doi.org/10.1016/0006-8993(88)90520-3

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