Antimitochondrial antibodies in primary biliary cirrhosis

The role of xenobiotics

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Primary biliary cirrhosis is an enigmatic autoimmune disease of women characterized by antimitochondrial antibodies and destruction of intrahepatic bile ducts. The etiology of PBC is unknown, but we present data herein that the disease may be induced by xenobiotic (i.e. chemicals) exposure. In particular, we postulate that halogenated compounds will bind to the autoantigen, break tolerance, and lead to an intense mucosal response.

Original languageEnglish (US)
Pages (from-to)37-42
Number of pages6
JournalAutoimmunity Reviews
Volume1
Issue number1-2
DOIs
StatePublished - Feb 2002

Fingerprint

Intrahepatic Bile Ducts
Biliary Liver Cirrhosis
Xenobiotics
Autoimmune Diseases
Antibodies
To autoantigen

Keywords

  • Antimitochondrial antibodies
  • Lipoic acid
  • Primary biliary cirrhosis
  • Pyruvate dehydrogenase
  • Xenobiotics

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Antimitochondrial antibodies in primary biliary cirrhosis : The role of xenobiotics. / Long, S. Alice; Van de Water, Judith A; Gershwin, M. Eric.

In: Autoimmunity Reviews, Vol. 1, No. 1-2, 02.2002, p. 37-42.

Research output: Contribution to journalArticle

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