Antimitochondrial antibodies in primary biliary cirrhosis: The role of xenobiotics

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34 Scopus citations

Abstract

Primary biliary cirrhosis is an enigmatic autoimmune disease of women characterized by antimitochondrial antibodies and destruction of intrahepatic bile ducts. The etiology of PBC is unknown, but we present data herein that the disease may be induced by xenobiotic (i.e. chemicals) exposure. In particular, we postulate that halogenated compounds will bind to the autoantigen, break tolerance, and lead to an intense mucosal response.

Original languageEnglish (US)
Pages (from-to)37-42
Number of pages6
JournalAutoimmunity Reviews
Volume1
Issue number1-2
DOIs
StatePublished - Feb 2002

Keywords

  • Antimitochondrial antibodies
  • Lipoic acid
  • Primary biliary cirrhosis
  • Pyruvate dehydrogenase
  • Xenobiotics

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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