Antimicrobial susceptibility patterns in urinary tract infections in dogs (2010-2013)

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Abstract

Background: Urinary tract infections (UTIs) are common in dogs. The responsible bacterial populations have evolved with increasing resistance to many antimicrobials. Objective: To characterize the antimicrobial susceptibility patterns of canine urinary tract isolates over a 51-month period. Animals: One thousand six hundred and thirty-six bacterial isolates from 1,028 dogs. Methods: Aerobic bacterial isolate growth and susceptibility data from urine cultures of dogs were identified, retrospectively. Medical records were reviewed to obtain signalment, comorbidities, and antimicrobial use in the previous 30 days. The UTIs were further categorized as uncomplicated, complicated, or pyelonephritis. Results: Common bacterial isolates identified were Escherichia coli (52.5%), Staphylococcus spp. (13.6%), and Enterococcus spp. (13.3%). In vitro susceptibility among all isolates varied for commonly prescribed antimicrobials (amoxicillin [59%], amoxicillin/clavulanic acid [76%], cephalexin [66%], enrofloxacin [74%] and trimethoprim-sulfamethoxazole [86%]). For all antimicrobials tested (except aminoglycosides), in vitro susceptibility was higher in uncomplicated versus complicated infections (P <.05). Uncomplicated infection isolate susceptibility rates remained ≤90% for PO administered antimicrobials. Administration of amoxicillin, doxycycline, and enrofloxacin, but not amoxicillin/clavulanic acid in the previous 30 days was associated with resistance to that antimicrobial. Multidrug resistant isolates of E. coli and Staphylococcus spp. were more common in dogs with complicated than uncomplicated UTIs (36% versus 21%, P <.0001). Conclusions and Clinical Importance: In vitro susceptibility was highly variable and no PO administered antimicrobial had >90% efficacy among isolates tested. Multidrug resistance was frequent among isolates tested suggesting that routine culture and susceptibility testing is indicated. Previously prescribed antimicrobials may affect empirical choices made pending susceptibility testing.

Original languageEnglish (US)
Pages (from-to)1045-1052
Number of pages8
JournalJournal of Veterinary Internal Medicine
Volume29
Issue number4
DOIs
StatePublished - 2015

Fingerprint

urinary tract diseases
Urinary Tract Infections
anti-infective agents
Dogs
dogs
Cephalexin
Amoxicillin-Potassium Clavulanate Combination
amoxicillin
Pyelonephritis
Amoxicillin
Sulfamethoxazole Drug Combination Trimethoprim
Enterococcus
Multiple Drug Resistance
Aminoglycosides
Urinary Tract
Staphylococcus
Medical Records
Canidae
Comorbidity
Urine

Keywords

  • Antimicrobial resistance
  • Bacterial resistance
  • Culture and susceptibility
  • Pyelonephritis
  • Uropathogens

ASJC Scopus subject areas

  • veterinary(all)

Cite this

@article{de7c03902f914ddbacc5fbe6b2381a7c,
title = "Antimicrobial susceptibility patterns in urinary tract infections in dogs (2010-2013)",
abstract = "Background: Urinary tract infections (UTIs) are common in dogs. The responsible bacterial populations have evolved with increasing resistance to many antimicrobials. Objective: To characterize the antimicrobial susceptibility patterns of canine urinary tract isolates over a 51-month period. Animals: One thousand six hundred and thirty-six bacterial isolates from 1,028 dogs. Methods: Aerobic bacterial isolate growth and susceptibility data from urine cultures of dogs were identified, retrospectively. Medical records were reviewed to obtain signalment, comorbidities, and antimicrobial use in the previous 30 days. The UTIs were further categorized as uncomplicated, complicated, or pyelonephritis. Results: Common bacterial isolates identified were Escherichia coli (52.5{\%}), Staphylococcus spp. (13.6{\%}), and Enterococcus spp. (13.3{\%}). In vitro susceptibility among all isolates varied for commonly prescribed antimicrobials (amoxicillin [59{\%}], amoxicillin/clavulanic acid [76{\%}], cephalexin [66{\%}], enrofloxacin [74{\%}] and trimethoprim-sulfamethoxazole [86{\%}]). For all antimicrobials tested (except aminoglycosides), in vitro susceptibility was higher in uncomplicated versus complicated infections (P <.05). Uncomplicated infection isolate susceptibility rates remained ≤90{\%} for PO administered antimicrobials. Administration of amoxicillin, doxycycline, and enrofloxacin, but not amoxicillin/clavulanic acid in the previous 30 days was associated with resistance to that antimicrobial. Multidrug resistant isolates of E. coli and Staphylococcus spp. were more common in dogs with complicated than uncomplicated UTIs (36{\%} versus 21{\%}, P <.0001). Conclusions and Clinical Importance: In vitro susceptibility was highly variable and no PO administered antimicrobial had >90{\%} efficacy among isolates tested. Multidrug resistance was frequent among isolates tested suggesting that routine culture and susceptibility testing is indicated. Previously prescribed antimicrobials may affect empirical choices made pending susceptibility testing.",
keywords = "Antimicrobial resistance, Bacterial resistance, Culture and susceptibility, Pyelonephritis, Uropathogens",
author = "C. Wong and Epstein, {Steven E} and Westropp, {Joellen L}",
year = "2015",
doi = "10.1111/jvim.13571",
language = "English (US)",
volume = "29",
pages = "1045--1052",
journal = "Journal of Veterinary Internal Medicine",
issn = "0891-6640",
publisher = "Wiley-Blackwell",
number = "4",

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TY - JOUR

T1 - Antimicrobial susceptibility patterns in urinary tract infections in dogs (2010-2013)

AU - Wong, C.

AU - Epstein, Steven E

AU - Westropp, Joellen L

PY - 2015

Y1 - 2015

N2 - Background: Urinary tract infections (UTIs) are common in dogs. The responsible bacterial populations have evolved with increasing resistance to many antimicrobials. Objective: To characterize the antimicrobial susceptibility patterns of canine urinary tract isolates over a 51-month period. Animals: One thousand six hundred and thirty-six bacterial isolates from 1,028 dogs. Methods: Aerobic bacterial isolate growth and susceptibility data from urine cultures of dogs were identified, retrospectively. Medical records were reviewed to obtain signalment, comorbidities, and antimicrobial use in the previous 30 days. The UTIs were further categorized as uncomplicated, complicated, or pyelonephritis. Results: Common bacterial isolates identified were Escherichia coli (52.5%), Staphylococcus spp. (13.6%), and Enterococcus spp. (13.3%). In vitro susceptibility among all isolates varied for commonly prescribed antimicrobials (amoxicillin [59%], amoxicillin/clavulanic acid [76%], cephalexin [66%], enrofloxacin [74%] and trimethoprim-sulfamethoxazole [86%]). For all antimicrobials tested (except aminoglycosides), in vitro susceptibility was higher in uncomplicated versus complicated infections (P <.05). Uncomplicated infection isolate susceptibility rates remained ≤90% for PO administered antimicrobials. Administration of amoxicillin, doxycycline, and enrofloxacin, but not amoxicillin/clavulanic acid in the previous 30 days was associated with resistance to that antimicrobial. Multidrug resistant isolates of E. coli and Staphylococcus spp. were more common in dogs with complicated than uncomplicated UTIs (36% versus 21%, P <.0001). Conclusions and Clinical Importance: In vitro susceptibility was highly variable and no PO administered antimicrobial had >90% efficacy among isolates tested. Multidrug resistance was frequent among isolates tested suggesting that routine culture and susceptibility testing is indicated. Previously prescribed antimicrobials may affect empirical choices made pending susceptibility testing.

AB - Background: Urinary tract infections (UTIs) are common in dogs. The responsible bacterial populations have evolved with increasing resistance to many antimicrobials. Objective: To characterize the antimicrobial susceptibility patterns of canine urinary tract isolates over a 51-month period. Animals: One thousand six hundred and thirty-six bacterial isolates from 1,028 dogs. Methods: Aerobic bacterial isolate growth and susceptibility data from urine cultures of dogs were identified, retrospectively. Medical records were reviewed to obtain signalment, comorbidities, and antimicrobial use in the previous 30 days. The UTIs were further categorized as uncomplicated, complicated, or pyelonephritis. Results: Common bacterial isolates identified were Escherichia coli (52.5%), Staphylococcus spp. (13.6%), and Enterococcus spp. (13.3%). In vitro susceptibility among all isolates varied for commonly prescribed antimicrobials (amoxicillin [59%], amoxicillin/clavulanic acid [76%], cephalexin [66%], enrofloxacin [74%] and trimethoprim-sulfamethoxazole [86%]). For all antimicrobials tested (except aminoglycosides), in vitro susceptibility was higher in uncomplicated versus complicated infections (P <.05). Uncomplicated infection isolate susceptibility rates remained ≤90% for PO administered antimicrobials. Administration of amoxicillin, doxycycline, and enrofloxacin, but not amoxicillin/clavulanic acid in the previous 30 days was associated with resistance to that antimicrobial. Multidrug resistant isolates of E. coli and Staphylococcus spp. were more common in dogs with complicated than uncomplicated UTIs (36% versus 21%, P <.0001). Conclusions and Clinical Importance: In vitro susceptibility was highly variable and no PO administered antimicrobial had >90% efficacy among isolates tested. Multidrug resistance was frequent among isolates tested suggesting that routine culture and susceptibility testing is indicated. Previously prescribed antimicrobials may affect empirical choices made pending susceptibility testing.

KW - Antimicrobial resistance

KW - Bacterial resistance

KW - Culture and susceptibility

KW - Pyelonephritis

KW - Uropathogens

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