Antimicrobial stewardship programs that target only high-cost, broad-spectrum antimicrobials miss opportunities to reduce Clostridium difficile infections

Christine Bui, Elizabeth Zhu, Monica A. Donnelley, Machelle D. Wilson, Margaret Morita, Stuart H Cohen, Jennifer Brown

Research output: Contribution to journalArticle

5 Scopus citations


Antimicrobial stewardship programs are promoted as a strategy to reduce Clostridium difficile infections. We implemented an antimicrobial stewardship program comprised of formulary restriction plus prospective audit with feedback for high-cost and broad-spectrum antimicrobials. Subsequently, we reviewed all heath care facility–onset, health care facility–associated C difficile infections. We found that most of these infections were associated with the antecedent receipt of nonaudited, and often unnecessary, antimicrobials.

Original languageEnglish (US)
Pages (from-to)1684-1686
Number of pages3
JournalAmerican Journal of Infection Control
Issue number12
StatePublished - Dec 1 2016



  • Antimicrobial stewardship
  • Clostridium difficile

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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