Antifollicular cell-mediated and humoral immunity in canine alopecia areata

Thierry Olivry, Peter F Moore, Diane K. Naydan, Barry J. Puget, Verena K Affolter, Archie E. Kline

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

A combination of cellular and humoral immunological assaults directed against follicular matrical cells is suspected to cause alopecia areata (AA) in humans. The specific aims of this study were to determine whether cytotoxic T lymphocytes (CTL) were increased in the blood and skin lesions of canine AA. Additionally, we wished to determine if circulating antifollicular antibodies were present in the dog. Finally, we aimed to investigate whether bulbar inflammation was associated with decreased matrical cell proliferation and keratinocyte apoptosis. Canine AA lesions were infiltrated by intrabulbar CTL, perifollicular helper T cells and dendritic cells. A higher percentage of CTL was present in canine AA peripheral blood compared with that of normal dogs. Tissue-fixed and circulating antifollicular IgG antibodies were detected. Reduced matrical proliferation and increased keratinocyte apoptosis was observed in inflamed hair bulbs. This study demonstrates the existence of antifollicular cell-mediated and humoral immunological responses in canine AA.

Original languageEnglish (US)
Pages (from-to)67-79
Number of pages13
JournalVeterinary Dermatology
Volume7
Issue number2
StatePublished - Jun 1996

Fingerprint

Alopecia Areata
alopecia
Humoral Immunity
humoral immunity
Cellular Immunity
cell-mediated immunity
Canidae
Cytotoxic T-Lymphocytes
cytotoxic T-lymphocytes
dogs
Keratinocytes
keratinocytes
Dogs
Apoptosis
apoptosis
Antibodies
Helper-Inducer T-Lymphocytes
antibodies
Hair
Dendritic Cells

Keywords

  • Alopecia areata
  • Autoimmunity
  • Cytotoxic T lymphocytes
  • Dog
  • Hair follicles
  • Skin diseases

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Antifollicular cell-mediated and humoral immunity in canine alopecia areata. / Olivry, Thierry; Moore, Peter F; Naydan, Diane K.; Puget, Barry J.; Affolter, Verena K; Kline, Archie E.

In: Veterinary Dermatology, Vol. 7, No. 2, 06.1996, p. 67-79.

Research output: Contribution to journalArticle

Olivry, T, Moore, PF, Naydan, DK, Puget, BJ, Affolter, VK & Kline, AE 1996, 'Antifollicular cell-mediated and humoral immunity in canine alopecia areata', Veterinary Dermatology, vol. 7, no. 2, pp. 67-79.
Olivry, Thierry ; Moore, Peter F ; Naydan, Diane K. ; Puget, Barry J. ; Affolter, Verena K ; Kline, Archie E. / Antifollicular cell-mediated and humoral immunity in canine alopecia areata. In: Veterinary Dermatology. 1996 ; Vol. 7, No. 2. pp. 67-79.
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