Abstract
The feasibility of gamma (γ)-interferon injection for the treatment of ocular fibrotic conditions was studied in rabbits using recombinant rabbit γ-interferon and the cell-injection model of tractional detachment. A toxicity study revealed that intravitreal injection of >104 units γ-interferon consistently produced panuveitis. For tractional detachment, 250,000 rabbit dermal fibroblasts were injected intravitreally into 20 eyes; 1 day later, 5 of these eyes received intravitreal injections of 104 units γ-interferon, another 5 were given 106 units, and the remaining 10 received balanced salt solution. Slit-lamp examination and fundus photography were performed at regular intervals for 21 days and were graded by a masked observer. The eyes were then enucleated and processed for histology. Doses of 104 units γ-interferon significantly reduced the severity of detachments, but injections of 106 units induced panuveitis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 84-90 |
| Number of pages | 7 |
| Journal | Graefe's Archive for Clinical and Experimental Ophthalmology |
| Volume | 230 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1992 |
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ASJC Scopus subject areas
- Ophthalmology
Cite this
Antifibrotic and uveitogenic properties of gamma interferon in the rabbit eye. / Hjelmeland, Leonard M; Li, Jin Wen; Toth, Cynthia A.; Landers, Maurice B.
In: Graefe's Archive for Clinical and Experimental Ophthalmology, Vol. 230, No. 1, 01.1992, p. 84-90.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Antifibrotic and uveitogenic properties of gamma interferon in the rabbit eye
AU - Hjelmeland, Leonard M
AU - Li, Jin Wen
AU - Toth, Cynthia A.
AU - Landers, Maurice B.
PY - 1992/1
Y1 - 1992/1
N2 - The feasibility of gamma (γ)-interferon injection for the treatment of ocular fibrotic conditions was studied in rabbits using recombinant rabbit γ-interferon and the cell-injection model of tractional detachment. A toxicity study revealed that intravitreal injection of >104 units γ-interferon consistently produced panuveitis. For tractional detachment, 250,000 rabbit dermal fibroblasts were injected intravitreally into 20 eyes; 1 day later, 5 of these eyes received intravitreal injections of 104 units γ-interferon, another 5 were given 106 units, and the remaining 10 received balanced salt solution. Slit-lamp examination and fundus photography were performed at regular intervals for 21 days and were graded by a masked observer. The eyes were then enucleated and processed for histology. Doses of 104 units γ-interferon significantly reduced the severity of detachments, but injections of 106 units induced panuveitis.
AB - The feasibility of gamma (γ)-interferon injection for the treatment of ocular fibrotic conditions was studied in rabbits using recombinant rabbit γ-interferon and the cell-injection model of tractional detachment. A toxicity study revealed that intravitreal injection of >104 units γ-interferon consistently produced panuveitis. For tractional detachment, 250,000 rabbit dermal fibroblasts were injected intravitreally into 20 eyes; 1 day later, 5 of these eyes received intravitreal injections of 104 units γ-interferon, another 5 were given 106 units, and the remaining 10 received balanced salt solution. Slit-lamp examination and fundus photography were performed at regular intervals for 21 days and were graded by a masked observer. The eyes were then enucleated and processed for histology. Doses of 104 units γ-interferon significantly reduced the severity of detachments, but injections of 106 units induced panuveitis.
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UR - http://www.scopus.com/inward/citedby.url?scp=0026518477&partnerID=8YFLogxK
U2 - 10.1007/BF00166768
DO - 10.1007/BF00166768
M3 - Article
C2 - 1547974
AN - SCOPUS:0026518477
VL - 230
SP - 84
EP - 90
JO - Albrecht von Graefes Archiv für Klinische und Experimentelle Ophthalmologie
JF - Albrecht von Graefes Archiv für Klinische und Experimentelle Ophthalmologie
SN - 0065-6100
IS - 1
ER -