Antifibrotic and uveitogenic properties of gamma interferon in the rabbit eye

Leonard M Hjelmeland, Jin Wen Li, Cynthia A. Toth, Maurice B. Landers

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The feasibility of gamma (γ)-interferon injection for the treatment of ocular fibrotic conditions was studied in rabbits using recombinant rabbit γ-interferon and the cell-injection model of tractional detachment. A toxicity study revealed that intravitreal injection of >104 units γ-interferon consistently produced panuveitis. For tractional detachment, 250,000 rabbit dermal fibroblasts were injected intravitreally into 20 eyes; 1 day later, 5 of these eyes received intravitreal injections of 104 units γ-interferon, another 5 were given 106 units, and the remaining 10 received balanced salt solution. Slit-lamp examination and fundus photography were performed at regular intervals for 21 days and were graded by a masked observer. The eyes were then enucleated and processed for histology. Doses of 104 units γ-interferon significantly reduced the severity of detachments, but injections of 106 units induced panuveitis.

Original languageEnglish (US)
Pages (from-to)84-90
Number of pages7
JournalGraefe's Archive for Clinical and Experimental Ophthalmology
Volume230
Issue number1
DOIs
StatePublished - Jan 1992

ASJC Scopus subject areas

  • Ophthalmology

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