Antifibrotic and uveitogenic properties of gamma interferon in the rabbit eye

Leonard M Hjelmeland; Jin Wen Li; Cynthia A. Toth; Maurice B. Landers

doi:10.1007/BF00166768

Antifibrotic and uveitogenic properties of gamma interferon in the rabbit eye

Leonard M Hjelmeland, Jin Wen Li, Cynthia A. Toth, Maurice B. Landers

Ophthalmology and Vision Science

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The feasibility of gamma (γ)-interferon injection for the treatment of ocular fibrotic conditions was studied in rabbits using recombinant rabbit γ-interferon and the cell-injection model of tractional detachment. A toxicity study revealed that intravitreal injection of >10⁴ units γ-interferon consistently produced panuveitis. For tractional detachment, 250,000 rabbit dermal fibroblasts were injected intravitreally into 20 eyes; 1 day later, 5 of these eyes received intravitreal injections of 10⁴ units γ-interferon, another 5 were given 10⁶ units, and the remaining 10 received balanced salt solution. Slit-lamp examination and fundus photography were performed at regular intervals for 21 days and were graded by a masked observer. The eyes were then enucleated and processed for histology. Doses of 10⁴ units γ-interferon significantly reduced the severity of detachments, but injections of 10⁶ units induced panuveitis.

Original language	English (US)
Pages (from-to)	84-90
Number of pages	7
Journal	Graefe's Archive for Clinical and Experimental Ophthalmology
Volume	230
Issue number	1
DOIs	https://doi.org/10.1007/BF00166768
State	Published - Jan 1992

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Ophthalmology

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title = "Antifibrotic and uveitogenic properties of gamma interferon in the rabbit eye",

abstract = "The feasibility of gamma (γ)-interferon injection for the treatment of ocular fibrotic conditions was studied in rabbits using recombinant rabbit γ-interferon and the cell-injection model of tractional detachment. A toxicity study revealed that intravitreal injection of >104 units γ-interferon consistently produced panuveitis. For tractional detachment, 250,000 rabbit dermal fibroblasts were injected intravitreally into 20 eyes; 1 day later, 5 of these eyes received intravitreal injections of 104 units γ-interferon, another 5 were given 106 units, and the remaining 10 received balanced salt solution. Slit-lamp examination and fundus photography were performed at regular intervals for 21 days and were graded by a masked observer. The eyes were then enucleated and processed for histology. Doses of 104 units γ-interferon significantly reduced the severity of detachments, but injections of 106 units induced panuveitis.",

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Antifibrotic and uveitogenic properties of gamma interferon in the rabbit eye

Abstract

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