Antidepressant treatment of veterans with Parkinson's disease and depression: Analysis of a national sample

Peijun Chen, Helen C. Kales, Daniel Weintraub, Frederic C. Blow, Lan Jiang, Alan M. Mellow

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

We examined the impact of comorbid Parkinson's disease (PD) on depression treatment. Using national Veterans Affairs (VA) databases, fiscal year 2002 data were examined for 283 273 elderly males seen for depression. We compared 2 matched depression groups, one with (N = 7868) and one without (N = 7868) PD. In the 12-month period following a depression-related clinic visit, PD and non-PD patients were equally likely to fill an antidepressant prescription (77.8% vs. 77.4%), most commonly for a selective serotonin re-uptake inhibitor (SSRI) (62.9% vs 62.6%). Depressed PD patients had slightly higher rates of newer non-SSRI use (20.6% vs 19.2%, P <.05) and lower rates of tricyclic antidepressant use (7.4% vs 8.9%, P <.001). The presence of a PD diagnosis appears to have little impact on the frequency and type of antidepressant treatment. Efforts to improve the care of depressed PD patients should focus instead on improving recognition, ensuring adequacy of treatment, and evaluating the efficacy of existing antidepressants.

Original languageEnglish (US)
Pages (from-to)161-165
Number of pages5
JournalJournal of Geriatric Psychiatry and Neurology
Volume20
Issue number3
DOIs
StatePublished - Sep 1 2007
Externally publishedYes

Fingerprint

Veterans
Antidepressive Agents
Parkinson Disease
Serotonin Uptake Inhibitors
Therapeutics
Tricyclic Antidepressive Agents
Ambulatory Care
Prescriptions
Research Design
Databases

Keywords

  • Antidepressants
  • Depression
  • Parkinson's disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

Antidepressant treatment of veterans with Parkinson's disease and depression : Analysis of a national sample. / Chen, Peijun; Kales, Helen C.; Weintraub, Daniel; Blow, Frederic C.; Jiang, Lan; Mellow, Alan M.

In: Journal of Geriatric Psychiatry and Neurology, Vol. 20, No. 3, 01.09.2007, p. 161-165.

Research output: Contribution to journalArticle

Chen, Peijun ; Kales, Helen C. ; Weintraub, Daniel ; Blow, Frederic C. ; Jiang, Lan ; Mellow, Alan M. / Antidepressant treatment of veterans with Parkinson's disease and depression : Analysis of a national sample. In: Journal of Geriatric Psychiatry and Neurology. 2007 ; Vol. 20, No. 3. pp. 161-165.
@article{4569f52fac384619ad9228836f75e86b,
title = "Antidepressant treatment of veterans with Parkinson's disease and depression: Analysis of a national sample",
abstract = "We examined the impact of comorbid Parkinson's disease (PD) on depression treatment. Using national Veterans Affairs (VA) databases, fiscal year 2002 data were examined for 283 273 elderly males seen for depression. We compared 2 matched depression groups, one with (N = 7868) and one without (N = 7868) PD. In the 12-month period following a depression-related clinic visit, PD and non-PD patients were equally likely to fill an antidepressant prescription (77.8{\%} vs. 77.4{\%}), most commonly for a selective serotonin re-uptake inhibitor (SSRI) (62.9{\%} vs 62.6{\%}). Depressed PD patients had slightly higher rates of newer non-SSRI use (20.6{\%} vs 19.2{\%}, P <.05) and lower rates of tricyclic antidepressant use (7.4{\%} vs 8.9{\%}, P <.001). The presence of a PD diagnosis appears to have little impact on the frequency and type of antidepressant treatment. Efforts to improve the care of depressed PD patients should focus instead on improving recognition, ensuring adequacy of treatment, and evaluating the efficacy of existing antidepressants.",
keywords = "Antidepressants, Depression, Parkinson's disease",
author = "Peijun Chen and Kales, {Helen C.} and Daniel Weintraub and Blow, {Frederic C.} and Lan Jiang and Mellow, {Alan M.}",
year = "2007",
month = "9",
day = "1",
doi = "10.1177/0891988707301866",
language = "English (US)",
volume = "20",
pages = "161--165",
journal = "Journal of Geriatric Psychiatry and Neurology",
issn = "0891-9887",
publisher = "SAGE Publications Inc.",
number = "3",

}

TY - JOUR

T1 - Antidepressant treatment of veterans with Parkinson's disease and depression

T2 - Analysis of a national sample

AU - Chen, Peijun

AU - Kales, Helen C.

AU - Weintraub, Daniel

AU - Blow, Frederic C.

AU - Jiang, Lan

AU - Mellow, Alan M.

PY - 2007/9/1

Y1 - 2007/9/1

N2 - We examined the impact of comorbid Parkinson's disease (PD) on depression treatment. Using national Veterans Affairs (VA) databases, fiscal year 2002 data were examined for 283 273 elderly males seen for depression. We compared 2 matched depression groups, one with (N = 7868) and one without (N = 7868) PD. In the 12-month period following a depression-related clinic visit, PD and non-PD patients were equally likely to fill an antidepressant prescription (77.8% vs. 77.4%), most commonly for a selective serotonin re-uptake inhibitor (SSRI) (62.9% vs 62.6%). Depressed PD patients had slightly higher rates of newer non-SSRI use (20.6% vs 19.2%, P <.05) and lower rates of tricyclic antidepressant use (7.4% vs 8.9%, P <.001). The presence of a PD diagnosis appears to have little impact on the frequency and type of antidepressant treatment. Efforts to improve the care of depressed PD patients should focus instead on improving recognition, ensuring adequacy of treatment, and evaluating the efficacy of existing antidepressants.

AB - We examined the impact of comorbid Parkinson's disease (PD) on depression treatment. Using national Veterans Affairs (VA) databases, fiscal year 2002 data were examined for 283 273 elderly males seen for depression. We compared 2 matched depression groups, one with (N = 7868) and one without (N = 7868) PD. In the 12-month period following a depression-related clinic visit, PD and non-PD patients were equally likely to fill an antidepressant prescription (77.8% vs. 77.4%), most commonly for a selective serotonin re-uptake inhibitor (SSRI) (62.9% vs 62.6%). Depressed PD patients had slightly higher rates of newer non-SSRI use (20.6% vs 19.2%, P <.05) and lower rates of tricyclic antidepressant use (7.4% vs 8.9%, P <.001). The presence of a PD diagnosis appears to have little impact on the frequency and type of antidepressant treatment. Efforts to improve the care of depressed PD patients should focus instead on improving recognition, ensuring adequacy of treatment, and evaluating the efficacy of existing antidepressants.

KW - Antidepressants

KW - Depression

KW - Parkinson's disease

UR - http://www.scopus.com/inward/record.url?scp=34547806581&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34547806581&partnerID=8YFLogxK

U2 - 10.1177/0891988707301866

DO - 10.1177/0891988707301866

M3 - Article

C2 - 17712099

AN - SCOPUS:34547806581

VL - 20

SP - 161

EP - 165

JO - Journal of Geriatric Psychiatry and Neurology

JF - Journal of Geriatric Psychiatry and Neurology

SN - 0891-9887

IS - 3

ER -