Abstract
Male Long-Evans rats were stereotaxically implanted with a bipolar electrode in the central amygdala and with a stainless-steel cannula in the lateral cerebral ventricle. Rats were then kindled once daily until 3 consecutive Stage 5 kindled seizures were elicited. Adenosine analogues were injected into the lateral cerebral ventricle to examine their effects on behavioral seizures and afterdischarge duration following a kindling stimulus. 5'-N-ethylcarboxamidoadenosine (NECA) and (-)-N-(1-methyl-2-phenylethyl)-adenosine(l-phenylisopropyladenosine) (l-PIA) produced dose-related reductions of amygdaloid-kindled seizures with NECA exhibiting slightly more potent anticonvulsant activity than l-PIA. Parenteral injections of caffeine, at a dose which had no effect on seizure parameters, antagonized the anticonvulsant effects of NECA. These results are consistent with the notion that adenosine is a modulator of synaptic activity in the CNS and methylxanthines exert a specific antagonism of central adenosine receptors.
Original language | English (US) |
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Pages (from-to) | 317-322 |
Number of pages | 6 |
Journal | Neuroscience Letters |
Volume | 46 |
Issue number | 3 |
DOIs | |
State | Published - May 18 1984 |
Externally published | Yes |
Keywords
- adenosine analogues
- adenosine receptors
- amygdala
- caffeine
- kindling
ASJC Scopus subject areas
- Neuroscience(all)