Anticonvulsant effects of adenosine analogues on amygdaloid-kindled seizures in rats

Robin A. Barraco, Thomas H. Swanson, John W. Phillis, Robert F Berman

Research output: Contribution to journalArticle

102 Scopus citations

Abstract

Male Long-Evans rats were stereotaxically implanted with a bipolar electrode in the central amygdala and with a stainless-steel cannula in the lateral cerebral ventricle. Rats were then kindled once daily until 3 consecutive Stage 5 kindled seizures were elicited. Adenosine analogues were injected into the lateral cerebral ventricle to examine their effects on behavioral seizures and afterdischarge duration following a kindling stimulus. 5'-N-ethylcarboxamidoadenosine (NECA) and (-)-N-(1-methyl-2-phenylethyl)-adenosine(l-phenylisopropyladenosine) (l-PIA) produced dose-related reductions of amygdaloid-kindled seizures with NECA exhibiting slightly more potent anticonvulsant activity than l-PIA. Parenteral injections of caffeine, at a dose which had no effect on seizure parameters, antagonized the anticonvulsant effects of NECA. These results are consistent with the notion that adenosine is a modulator of synaptic activity in the CNS and methylxanthines exert a specific antagonism of central adenosine receptors.

Original languageEnglish (US)
Pages (from-to)317-322
Number of pages6
JournalNeuroscience Letters
Volume46
Issue number3
DOIs
StatePublished - May 18 1984
Externally publishedYes

Keywords

  • adenosine analogues
  • adenosine receptors
  • amygdala
  • caffeine
  • kindling

ASJC Scopus subject areas

  • Neuroscience(all)

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