Anticonvulsant drugs and their antagonism of kindled amygdaloid seizures in rats

Timothy E Albertson, S. L. Peterson, L. G. Stark

Research output: Contribution to journalArticle

126 Scopus citations

Abstract

The kindling phenomenon has become a useful animal model for studying the processes in the central nervous system involved in one type of epileptiform seizure response. A systematic, multipledose evaluation of 20 drugs known to have anticonvulsant properties and two new compounds (WB-CPI and SHK-I-11) is reported using a standard protocol with rats kindled by amygdaloid stimulation. Drugs which have a wide anticonvulsant spectrum of activity against various animal models of epilepsy were the most effective. The barbiturates, the benzodiazepines, a piperazine, an acetate derivative and WB-CPI (a significantly modified phenacylurea), were found to be the most effective in attenuating the induced seizures. Kindled amygdaloid seizures in the rat can be characterized as a model useful for the detection of a wide variety of anticonvulsants likely to be effective in many types of experimental seizures. The compound WB-CPI merits further neuropharmacological and psychopharmacological testing due to its activity in rats.

Original languageEnglish (US)
Pages (from-to)643-652
Number of pages10
JournalNeuropharmacology
Volume19
Issue number7
DOIs
StatePublished - 1980

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Drug Discovery
  • Pharmacology

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