Antibody responses against HIV in rhesus macaques following combinations of mucosal and systemic immunizations with chimeric alphavirus-based replicon particles

Soumi Gupta, Fengmin Zhou, Catherine E. Greer, Harold Legg, Tony Tang, Paul A Luciw, Jan Zur Megede, Susan W. Barnett, John J. Donnelly, Derek T. O'Hagan, John M. Polo, Michael Vajdy

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13 Scopus citations

Abstract

Mucosal and systemic transmission of HIV is prevalent. Therefore, mucosal followed by parenteral immunizations with chimeric vs. complete alphaviras-based replicon particles, encoding an HIV envelope glycoprotein, were tested. Female rliesus macaques were immunized intranasally and then intramuscularly. Following the immunizations, enhanced mucosal and systemic antibody responses were detected with the chimeric compared to the complete replicon particles. Although similar proportions of the same peripheral blood monocyte lineage target cells were infected with the chimeric vs. the complete replicon particles, the latter resulted in enhanced expression of the gene of interest, suggesting a possible mechanism of the enhanced immunogenicity.

Original languageEnglish (US)
Pages (from-to)993-997
Number of pages5
JournalAIDS Research and Human Retroviruses
Volume22
Issue number10
DOIs
StatePublished - Oct 2006

ASJC Scopus subject areas

  • Immunology
  • Virology

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    Gupta, S., Zhou, F., Greer, C. E., Legg, H., Tang, T., Luciw, P. A., Zur Megede, J., Barnett, S. W., Donnelly, J. J., O'Hagan, D. T., Polo, J. M., & Vajdy, M. (2006). Antibody responses against HIV in rhesus macaques following combinations of mucosal and systemic immunizations with chimeric alphavirus-based replicon particles. AIDS Research and Human Retroviruses, 22(10), 993-997. https://doi.org/10.1089/aid.2006.22.993