Antibody response of two populations of common carp, Cyprinus carpio L., exposed to koi herpesvirus

S. St-Hilaire, N. Beevers, C. Joiner, Ronald Hedrick, K. Way

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

Common carp, Cyprinus carpio L., exp7osed to koi herpesvirus (KHV) may become persistently infected and populations containing such virus-infected individuals may transmit the virus to other fish when co-habited. Detection of virus-infected fish in a population is thus critical to surveillance and control programmes for KHV. A study was therefore designed to detect anti-KHV serum antibodies, with an enzyme-linked immunosorbent assay, in common carp following experimental exposures to KHV under varying environmental conditions. The study determined that a proportion of fish within a population experimentally exposed to KHV (at least 10-25%) develop high antibody titres (1/1600 or greater) to the virus, and this immunological response was detectable for several months (observed at the termination of the experiments at 65, 46 and 27 weeks post-exposure). Furthermore, this response was detected in one population of fish that did not succumb to a high level of mortality when maintained at water temperatures that were non-permissive for KHV. Elevating the water temperatures to permissive conditions for KHV resulted in recurrence of disease despite the presence of anti-virus antibodies, suggesting that serum antibodies alone are not protective under the conditions of our trials.

Original languageEnglish (US)
Pages (from-to)311-320
Number of pages10
JournalJournal of Fish Diseases
Volume32
Issue number4
DOIs
StatePublished - Apr 1 2009

Keywords

  • Cyprinus carpio
  • Enzyme-linked immunosorbent assay
  • Koi herpesvirus
  • Persistent infections
  • Serology

ASJC Scopus subject areas

  • Aquatic Science
  • veterinary (miscalleneous)

Fingerprint Dive into the research topics of 'Antibody response of two populations of common carp, Cyprinus carpio L., exposed to koi herpesvirus'. Together they form a unique fingerprint.

Cite this