Antibody is required for protection against virulent but not attenuated Salmonella enterica serovar typhimurium

Stephen J Mcsorley, Marc K. Jenkins

Research output: Contribution to journalArticlepeer-review

161 Scopus citations

Abstract

Resolution of infection with attenuated Salmonella is an active process that requires CD4+ T cells. Here, we demonstrate that costimulation via the surface molecule CD28, but not antibody production by B cells, is required for clearance of attenuated aroA Salmonella enterica serovar typhimurium. In contrast, specific antibody is critical for vaccine-induced protection against virulent bacteria. Therefore, CD28+ CD4+ T cells are sufficient for clearance of avirulent Salmonella in naive hosts, whereas CD4+ T cells and specific antibodies are required for protection from virulent Salmonella in immune hosts.

Original languageEnglish (US)
Pages (from-to)3344-3348
Number of pages5
JournalInfection and Immunity
Volume68
Issue number6
DOIs
StatePublished - Jun 2000
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

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