Antibody, but not B-cell–dependent antigen presentation, plays an essential role in preventing Chlamydia systemic dissemination in mice

Priyangi A. Malaviarachchi, Miguel A.B. Mercado, Stephen J. McSorley, Lin Xi Li

Research output: Contribution to journalArticle

Abstract

The obligate intracellular bacterium Chlamydia trachomatis causes the most prevalent bacterial sexually transmitted infection worldwide. CD4 T cells play a central role in the protective immunity against Chlamydia female reproductive tract (FRT) infection, while B cells are thought to be dispensable for resolution of primary Chlamydia infection in mouse models. We recently reported an unexpected requirement of B cells in local Chlamydia-specific CD4 T-cell priming and bacterial containment within the FRT. Here, we sought to tackle the precise effector function of B cells during Chlamydia primary infection. Using mixed bone marrow chimeras that lack B-cell–dependent Ag presentation (MHCIIB (Formula presented.)) or devoid of circulating antibodies (AID−/− × μS−/−), we show that Chlamydia-specific CD4 T-cell expansion does not rely on Ag presentation by B cells. Importantly, we demonstrate that antibody, but not B-cell–dependent Ag presentation, is required for preventing systemic bacterial dissemination following Chlamydia FRT infection.

Original languageEnglish (US)
Pages (from-to)676-684
Number of pages9
JournalEuropean Journal of Immunology
Volume50
Issue number5
DOIs
StatePublished - May 1 2020

Keywords

  • Antibody
  • Antigen presentation
  • B cells
  • Chlamydia
  • Infection

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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