Antibodies with infinite affinity: Origins and applications

Nathaniel G. Butlin; Claude F. Meares

doi:10.1021/ar020275e

Antibodies with infinite affinity: Origins and applications

Nathaniel G. Butlin, Claude F. Meares

Chemistry

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Antibodies with infinite affinity were developed with the aim of improving targeted delivery of metal complexes to sites of disease. This is part of a series of chemical technology developments for biomedical imaging and therapy. Using a combination of genetics and chemical synthesis, it addresses challenges in developing proteins that specifically bind synthetic molecules and do not release them. The result is a set of reagents that promise to capture any of a large variety of metallic elements under physiological conditions and hold them for long periods of time.

Original language	English (US)
Pages (from-to)	780-787
Number of pages	8
Journal	Accounts of Chemical Research
Volume	39
Issue number	10
DOIs	https://doi.org/10.1021/ar020275e
State	Published - Oct 2006

ASJC Scopus subject areas

Chemistry(all)

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10.1021/ar020275e

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abstract = "Antibodies with infinite affinity were developed with the aim of improving targeted delivery of metal complexes to sites of disease. This is part of a series of chemical technology developments for biomedical imaging and therapy. Using a combination of genetics and chemical synthesis, it addresses challenges in developing proteins that specifically bind synthetic molecules and do not release them. The result is a set of reagents that promise to capture any of a large variety of metallic elements under physiological conditions and hold them for long periods of time.",

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Antibodies with infinite affinity: Origins and applications

Abstract

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