Antibodies with infinite affinity: Origins and applications

Nathaniel G. Butlin; Claude F. Meares

doi:10.1021/ar020275e

Antibodies with infinite affinity: Origins and applications

Nathaniel G. Butlin, Claude F. Meares

Chemistry

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Antibodies with infinite affinity were developed with the aim of improving targeted delivery of metal complexes to sites of disease. This is part of a series of chemical technology developments for biomedical imaging and therapy. Using a combination of genetics and chemical synthesis, it addresses challenges in developing proteins that specifically bind synthetic molecules and do not release them. The result is a set of reagents that promise to capture any of a large variety of metallic elements under physiological conditions and hold them for long periods of time.

Original language	English (US)
Pages (from-to)	780-787
Number of pages	8
Journal	Accounts of Chemical Research
Volume	39
Issue number	10
DOIs	https://doi.org/10.1021/ar020275e
State	Published - Oct 2006

ASJC Scopus subject areas

Chemistry(all)

Access to Document

10.1021/ar020275e

Fingerprint Dive into the research topics of 'Antibodies with infinite affinity: Origins and applications'. Together they form a unique fingerprint.

Cite this

@article{1c40c6c473a0401aa7e24657280c6d7f,

title = "Antibodies with infinite affinity: Origins and applications",

abstract = "Antibodies with infinite affinity were developed with the aim of improving targeted delivery of metal complexes to sites of disease. This is part of a series of chemical technology developments for biomedical imaging and therapy. Using a combination of genetics and chemical synthesis, it addresses challenges in developing proteins that specifically bind synthetic molecules and do not release them. The result is a set of reagents that promise to capture any of a large variety of metallic elements under physiological conditions and hold them for long periods of time.",

author = "Butlin, {Nathaniel G.} and Meares, {Claude F.}",

year = "2006",

month = oct,

doi = "10.1021/ar020275e",

language = "English (US)",

volume = "39",

pages = "780--787",

journal = "Accounts of Chemical Research",

issn = "0001-4842",

publisher = "American Chemical Society",

number = "10",

}

TY - JOUR

T1 - Antibodies with infinite affinity

T2 - Origins and applications

AU - Butlin, Nathaniel G.

AU - Meares, Claude F.

PY - 2006/10

Y1 - 2006/10

N2 - Antibodies with infinite affinity were developed with the aim of improving targeted delivery of metal complexes to sites of disease. This is part of a series of chemical technology developments for biomedical imaging and therapy. Using a combination of genetics and chemical synthesis, it addresses challenges in developing proteins that specifically bind synthetic molecules and do not release them. The result is a set of reagents that promise to capture any of a large variety of metallic elements under physiological conditions and hold them for long periods of time.

AB - Antibodies with infinite affinity were developed with the aim of improving targeted delivery of metal complexes to sites of disease. This is part of a series of chemical technology developments for biomedical imaging and therapy. Using a combination of genetics and chemical synthesis, it addresses challenges in developing proteins that specifically bind synthetic molecules and do not release them. The result is a set of reagents that promise to capture any of a large variety of metallic elements under physiological conditions and hold them for long periods of time.

UR - http://www.scopus.com/inward/record.url?scp=33750604650&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33750604650&partnerID=8YFLogxK

U2 - 10.1021/ar020275e

DO - 10.1021/ar020275e

M3 - Article

C2 - 17042478

AN - SCOPUS:33750604650

VL - 39

SP - 780

EP - 787

JO - Accounts of Chemical Research

JF - Accounts of Chemical Research

SN - 0001-4842

IS - 10

ER -

Antibodies with infinite affinity: Origins and applications

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this