Antibodies with infinite affinity: Origins and applications

Nathaniel G. Butlin, Claude F. Meares

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Antibodies with infinite affinity were developed with the aim of improving targeted delivery of metal complexes to sites of disease. This is part of a series of chemical technology developments for biomedical imaging and therapy. Using a combination of genetics and chemical synthesis, it addresses challenges in developing proteins that specifically bind synthetic molecules and do not release them. The result is a set of reagents that promise to capture any of a large variety of metallic elements under physiological conditions and hold them for long periods of time.

Original languageEnglish (US)
Pages (from-to)780-787
Number of pages8
JournalAccounts of Chemical Research
Volume39
Issue number10
DOIs
StatePublished - Oct 2006

ASJC Scopus subject areas

  • Chemistry(all)

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