Antibodies with infinite affinity: Origins and applications

Nathaniel G. Butlin, Claude F. Meares

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Antibodies with infinite affinity were developed with the aim of improving targeted delivery of metal complexes to sites of disease. This is part of a series of chemical technology developments for biomedical imaging and therapy. Using a combination of genetics and chemical synthesis, it addresses challenges in developing proteins that specifically bind synthetic molecules and do not release them. The result is a set of reagents that promise to capture any of a large variety of metallic elements under physiological conditions and hold them for long periods of time.

Original languageEnglish (US)
Pages (from-to)780-787
Number of pages8
JournalAccounts of Chemical Research
Volume39
Issue number10
DOIs
StatePublished - Oct 2006

ASJC Scopus subject areas

  • Chemistry(all)

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