Antibodies to the thyroid gland and to the thyrotrophin receptor in African and Indian thyrotoxic patients

R. K. Desai, I. Jialal, M. A K Omar, M. C. Rajput, S. M. Joubert

Research output: Contribution to journalArticle

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Abstract

Sixty two thyrotoxic patients, 34 African and 28 Indian, were studied in order to assess the prevalence of thyroid antibodies and TSH binding inhibitory activity (TBI): 45 had Graves' disease and 17 had toxic nodular goitres. Microsomal and thyroglobulin antibodies were positive more often in Indian than in African patients with Graves' disease (microsomal 52% vs 37.4%, Plt;0.05; thyroglobulin 38.1% vs 4.2%, P<0.001). Patients with toxic nodular goitres had a lower prevalence of positive microsomal antibodies (Plt;0.01), but not of thyroglobulin antibodies (P = 0.1) when compared with patients with Graves' disease. TBI activity measured by a radioreceptor assay was positive in 43 of the 45 (95%) patients with Graves' disease and only 1 ofthe 17 patients (5.9%) with toxic nodular goitre. It thus appears that TBI activity is a sensitive marker in the diagnosis of Graves' disease and that there is a lower prevalence ofthyroglobulin and microsomal antibodies in African patients compared with Indian patients.

Original languageEnglish (US)
Pages (from-to)837-839
Number of pages3
JournalPostgraduate Medical Journal
Volume62
Issue number731
DOIs
StatePublished - 1986
Externally publishedYes

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Thyrotropin
Thyroid Gland
Graves Disease
Antibodies
Nodular Goiter
Thyroglobulin
Poisons
Radioligand Assay

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Epidemiology
  • Medicine(all)

Cite this

Antibodies to the thyroid gland and to the thyrotrophin receptor in African and Indian thyrotoxic patients. / Desai, R. K.; Jialal, I.; Omar, M. A K; Rajput, M. C.; Joubert, S. M.

In: Postgraduate Medical Journal, Vol. 62, No. 731, 1986, p. 837-839.

Research output: Contribution to journalArticle

Desai, R. K. ; Jialal, I. ; Omar, M. A K ; Rajput, M. C. ; Joubert, S. M. / Antibodies to the thyroid gland and to the thyrotrophin receptor in African and Indian thyrotoxic patients. In: Postgraduate Medical Journal. 1986 ; Vol. 62, No. 731. pp. 837-839.
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