Antibodies to P2 and P1 myelin antigens in experimental allergic neuritis and allergic encephalomyelitis

Burton Zweiman, Anne R. Moskovitz, Abdolmohammad Rostami, Robert P. Lisak, David E Pleasure, Mark J. Brown

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

We confirmed earlier observations that experimental allergic neuritis (EAN) in Lewis rats induced by injection of bovine peripheral nerve myelin in complete Freund's adjuvant is not accompanied by development of experimental allergic encephalomyelitis. However, sera of these animals contained elevated titers of antibodies against central nervous system myelin basic protein (BP), likely induced by peripheral nerve P1 protein. Anti-BP antibodies were not seen in sera of rats with EAN induced by peripheral nerve P2 protein. Lack of encephalogenecity of bovine myelin in Lewis rats does not reflect simply lack of immune responses induced against BP.

Original languageEnglish (US)
Pages (from-to)331-336
Number of pages6
JournalJournal of Neuroimmunology
Volume2
Issue number3-4
DOIs
StatePublished - 1982
Externally publishedYes

Keywords

  • Experimental allergic encephalomyelitis
  • Experimental allergic neuritis
  • Myelin
  • P
  • P

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Clinical Neurology
  • Neurology

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