Antibodies to phocine herpesvirus-1 are common in North American harbor seals (Phoca Vitulina)

Tracey Goldstein, Frances M D Gulland, Brian M. Aldridge, James T. Harvey, Teri Rowles, Dyanna M. Lambourn, Steven J. Jeffries, Lena Measures, Pamela K. Yochem, Brent S. Stewart, Robert J. Small, Donald P. King, Jeffrey L Stott, Jonna A Mazet

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Phocine herpesvirus-1 (PhHV-1) has been associated with morbidity and high mortality in neonatal harbor seals (Phoca vitulina) along the Pacific coast of California (USA) and in northern Europe. Seals dying with PhHV-1 associated disease in California primarily have histopathologic evidence of adrenal necrosis or adrenalitis with herpesviral inclusion bodies. Little is known about prevalence of exposure to PhHV-1, modes of disease transmission, and viral pathogenesis in free-ranging harbor seal populations. To evaluate the prevalence in North America, 866 serum samples collected between 1994 and 2002 from harbor seals captured or stranded on the Pacific and Atlantic coasts of North America were assayed by enzyme linked immunosorbent assay (ELISA) for evidence of PhHV-1 exposure. Samples from three harbor seal age classes (pre-weaned, weaned, and subadults/adults) were obtained from each of four regions to compare exposure among sex, age class, and region. We found increasing prevalence with age as 37.5% of pre-weaned pups, 87.6% of weaned pups, and 99.0% of subadults and adults were seropositive. When accounting for age, no associations between seropositivity and sex or location of harbor seals were detected. These data indicate that PhHV-1 is endemic in the harbor seal populations of North America.

Original languageEnglish (US)
Pages (from-to)487-494
Number of pages8
JournalJournal of Wildlife Diseases
Volume39
Issue number3
StatePublished - Jul 2003

Fingerprint

Phoca
Phoca vitulina
Herpesviridae
antibody
harbor
antibodies
Antibodies
North America
age class
pups
age structure
disease transmission
coast
neonatal mortality
coasts
morbidity
gender
Inclusion Bodies
inclusion bodies
Northern European region

Keywords

  • ELISA
  • Harbor seal
  • Herpesvirus
  • Marine wildlife
  • PhHV-1
  • Phoca vitulina
  • Serosurvey

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Goldstein, T., Gulland, F. M. D., Aldridge, B. M., Harvey, J. T., Rowles, T., Lambourn, D. M., ... Mazet, J. A. (2003). Antibodies to phocine herpesvirus-1 are common in North American harbor seals (Phoca Vitulina). Journal of Wildlife Diseases, 39(3), 487-494.

Antibodies to phocine herpesvirus-1 are common in North American harbor seals (Phoca Vitulina). / Goldstein, Tracey; Gulland, Frances M D; Aldridge, Brian M.; Harvey, James T.; Rowles, Teri; Lambourn, Dyanna M.; Jeffries, Steven J.; Measures, Lena; Yochem, Pamela K.; Stewart, Brent S.; Small, Robert J.; King, Donald P.; Stott, Jeffrey L; Mazet, Jonna A.

In: Journal of Wildlife Diseases, Vol. 39, No. 3, 07.2003, p. 487-494.

Research output: Contribution to journalArticle

Goldstein, T, Gulland, FMD, Aldridge, BM, Harvey, JT, Rowles, T, Lambourn, DM, Jeffries, SJ, Measures, L, Yochem, PK, Stewart, BS, Small, RJ, King, DP, Stott, JL & Mazet, JA 2003, 'Antibodies to phocine herpesvirus-1 are common in North American harbor seals (Phoca Vitulina)', Journal of Wildlife Diseases, vol. 39, no. 3, pp. 487-494.
Goldstein T, Gulland FMD, Aldridge BM, Harvey JT, Rowles T, Lambourn DM et al. Antibodies to phocine herpesvirus-1 are common in North American harbor seals (Phoca Vitulina). Journal of Wildlife Diseases. 2003 Jul;39(3):487-494.
Goldstein, Tracey ; Gulland, Frances M D ; Aldridge, Brian M. ; Harvey, James T. ; Rowles, Teri ; Lambourn, Dyanna M. ; Jeffries, Steven J. ; Measures, Lena ; Yochem, Pamela K. ; Stewart, Brent S. ; Small, Robert J. ; King, Donald P. ; Stott, Jeffrey L ; Mazet, Jonna A. / Antibodies to phocine herpesvirus-1 are common in North American harbor seals (Phoca Vitulina). In: Journal of Wildlife Diseases. 2003 ; Vol. 39, No. 3. pp. 487-494.
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abstract = "Phocine herpesvirus-1 (PhHV-1) has been associated with morbidity and high mortality in neonatal harbor seals (Phoca vitulina) along the Pacific coast of California (USA) and in northern Europe. Seals dying with PhHV-1 associated disease in California primarily have histopathologic evidence of adrenal necrosis or adrenalitis with herpesviral inclusion bodies. Little is known about prevalence of exposure to PhHV-1, modes of disease transmission, and viral pathogenesis in free-ranging harbor seal populations. To evaluate the prevalence in North America, 866 serum samples collected between 1994 and 2002 from harbor seals captured or stranded on the Pacific and Atlantic coasts of North America were assayed by enzyme linked immunosorbent assay (ELISA) for evidence of PhHV-1 exposure. Samples from three harbor seal age classes (pre-weaned, weaned, and subadults/adults) were obtained from each of four regions to compare exposure among sex, age class, and region. We found increasing prevalence with age as 37.5{\%} of pre-weaned pups, 87.6{\%} of weaned pups, and 99.0{\%} of subadults and adults were seropositive. When accounting for age, no associations between seropositivity and sex or location of harbor seals were detected. These data indicate that PhHV-1 is endemic in the harbor seal populations of North America.",
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