Abstract
The presence of antibodies to native DNA, single-stranded DNA, and double-stranded RNA was determined for 37 patients with selective IgA deficiency, 11 patients with Wiskott-Aldrich syndrome, seven patients with common variable agammaglobulinemia, 14 patients with ataxia telangiectasia, six patients with intestinal lymphangiectasia, and one patient with Nezelof syndrome. Of 37 patients with selective IgA deficiency, 11 had antibodies to at least one nucleic acid; six had antibodies to native DNA, seven had antibodies to single-stranded DNA, and four had antibodies to double-stranded RNA. The only other congenital immune deficiency disease studied in which antibodies to nucleic acids were found was the Wiskott-Aldrich syndrome; in this group three of 11 patients had antibodies to native DNA. Retrospective analysis of our patients with SLE disclosed a 2.6% prevalence of IgA deficiency, a prevalence clearly higher than in the general population. These studies provide further evidence of the association between autoimmunity and abnormalities of IgA production and suggest a relationship between thymic-derived immune regulation and IgA production.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 377-381 |
| Number of pages | 5 |
| Journal | The Journal of Pediatrics |
| Volume | 89 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1976 |
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ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
Cite this
Antibodies to nucleic acids in congenital immune deficiency states. / Gershwin, M. Eric; Blaese, R. Michael; Steinberg, Alfred D.; Wistar, Richard; Strober, Warren.
In: The Journal of Pediatrics, Vol. 89, No. 3, 1976, p. 377-381.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Antibodies to nucleic acids in congenital immune deficiency states
AU - Gershwin, M. Eric
AU - Blaese, R. Michael
AU - Steinberg, Alfred D.
AU - Wistar, Richard
AU - Strober, Warren
PY - 1976
Y1 - 1976
N2 - The presence of antibodies to native DNA, single-stranded DNA, and double-stranded RNA was determined for 37 patients with selective IgA deficiency, 11 patients with Wiskott-Aldrich syndrome, seven patients with common variable agammaglobulinemia, 14 patients with ataxia telangiectasia, six patients with intestinal lymphangiectasia, and one patient with Nezelof syndrome. Of 37 patients with selective IgA deficiency, 11 had antibodies to at least one nucleic acid; six had antibodies to native DNA, seven had antibodies to single-stranded DNA, and four had antibodies to double-stranded RNA. The only other congenital immune deficiency disease studied in which antibodies to nucleic acids were found was the Wiskott-Aldrich syndrome; in this group three of 11 patients had antibodies to native DNA. Retrospective analysis of our patients with SLE disclosed a 2.6% prevalence of IgA deficiency, a prevalence clearly higher than in the general population. These studies provide further evidence of the association between autoimmunity and abnormalities of IgA production and suggest a relationship between thymic-derived immune regulation and IgA production.
AB - The presence of antibodies to native DNA, single-stranded DNA, and double-stranded RNA was determined for 37 patients with selective IgA deficiency, 11 patients with Wiskott-Aldrich syndrome, seven patients with common variable agammaglobulinemia, 14 patients with ataxia telangiectasia, six patients with intestinal lymphangiectasia, and one patient with Nezelof syndrome. Of 37 patients with selective IgA deficiency, 11 had antibodies to at least one nucleic acid; six had antibodies to native DNA, seven had antibodies to single-stranded DNA, and four had antibodies to double-stranded RNA. The only other congenital immune deficiency disease studied in which antibodies to nucleic acids were found was the Wiskott-Aldrich syndrome; in this group three of 11 patients had antibodies to native DNA. Retrospective analysis of our patients with SLE disclosed a 2.6% prevalence of IgA deficiency, a prevalence clearly higher than in the general population. These studies provide further evidence of the association between autoimmunity and abnormalities of IgA production and suggest a relationship between thymic-derived immune regulation and IgA production.
UR - http://www.scopus.com/inward/record.url?scp=0017114834&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0017114834&partnerID=8YFLogxK
U2 - 10.1016/S0022-3476(76)80531-8
DO - 10.1016/S0022-3476(76)80531-8
M3 - Article
C2 - 1085351
AN - SCOPUS:0017114834
VL - 89
SP - 377
EP - 381
JO - Journal of Pediatrics
JF - Journal of Pediatrics
SN - 0022-3476
IS - 3
ER -