Antibodies to β1 integrins inhibit dendritic growth in rat sympathetic neurons

Pamela J Lein, Dennis Higgins

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

We have examined the role of integrins in the development of dendrites in embryonic rat sympathetic neurons in vitro. Previous studies have established that exposure to a basement membrane extract (BME) causes these neurons to form dendrites (Lein and Higgins, 1989). The current experiments demonstrate that the dendrite-promoting activity of BME can be markedly inhibited by antibodies directed against the β1 integrin subunit. Although the specific α integrin sub-unit(s) that mediate the effect of BME on dendritic growth were not identified, it was found that neither the α1 or α4 sub-units, nor RGD-binding integrins were involved to any significant extent. These data suggest that, in addition to their well established role in regulating axonal growth, β1 integrins also participate in dendritic growth.

Original languageEnglish (US)
Pages (from-to)101-111
Number of pages11
JournalBiomedical Research (India)
Volume7
Issue number1
StatePublished - 1996
Externally publishedYes

Keywords

  • β1 integrins
  • Dendrite
  • Extracellular matrix
  • Matrigel
  • Neuronal development
  • Neuronal polarity
  • Sympathetic neurons

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Fingerprint Dive into the research topics of 'Antibodies to β<sub>1</sub> integrins inhibit dendritic growth in rat sympathetic neurons'. Together they form a unique fingerprint.

  • Cite this