Antibodies as enzymes

Richard A. Lerner, Alfonso Tramontano

Research output: Contribution to journalArticlepeer-review

68 Scopus citations


Enzymes may act as catalysts because they are more closely complementary to the transition state than to the substrate or product of a reaction. Monoclonal antibodies were raised to synthetic analogs of an esterolytic transition state. As predicted, some of these antibodies had catalytic activity.

Original languageEnglish (US)
Pages (from-to)427-430
Number of pages4
JournalTrends in Biochemical Sciences
Issue numberC
StatePublished - 1987
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry


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