Antibodies as enzymes

Richard A. Lerner, Alfonso Tramontano

Research output: Contribution to journalArticle

62 Scopus citations

Abstract

Enzymes may act as catalysts because they are more closely complementary to the transition state than to the substrate or product of a reaction. Monoclonal antibodies were raised to synthetic analogs of an esterolytic transition state. As predicted, some of these antibodies had catalytic activity.

Original languageEnglish (US)
Pages (from-to)427-430
Number of pages4
JournalTrends in Biochemical Sciences
Volume12
Issue numberC
DOIs
StatePublished - 1987
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry

Fingerprint Dive into the research topics of 'Antibodies as enzymes'. Together they form a unique fingerprint.

  • Cite this