Antibodies as enzymes

Richard A. Lerner, Alfonso Tramontano

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Enzymes may act as catalysts because they are more closely complementary to the transition state than to the substrate or product of a reaction. Monoclonal antibodies were raised to synthetic analogs of an esterolytic transition state. As predicted, some of these antibodies had catalytic activity.

Original languageEnglish (US)
Pages (from-to)427-430
Number of pages4
JournalTrends in Biochemical Sciences
Volume12
Issue numberC
DOIs
StatePublished - 1987
Externally publishedYes

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Catalytic Antibodies
Catalyst activity
Monoclonal Antibodies
Catalysts
Antibodies
Substrates
Enzymes

ASJC Scopus subject areas

  • Biochemistry

Cite this

Antibodies as enzymes. / Lerner, Richard A.; Tramontano, Alfonso.

In: Trends in Biochemical Sciences, Vol. 12, No. C, 1987, p. 427-430.

Research output: Contribution to journalArticle

Lerner, RA & Tramontano, A 1987, 'Antibodies as enzymes', Trends in Biochemical Sciences, vol. 12, no. C, pp. 427-430. https://doi.org/10.1016/0968-0004(87)90208-8
Lerner, Richard A. ; Tramontano, Alfonso. / Antibodies as enzymes. In: Trends in Biochemical Sciences. 1987 ; Vol. 12, No. C. pp. 427-430.
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