Anti-neutrophil cytoplasmic antibodies in patients with chromomycosis

C. Galperin, Y. Shoenfeld, B. Gilburd, P. Esterre, R. L. Meroni, N. Del Papa, G. M. Halpern, A. Andriantsimahavandy, M. Eric Gershwin

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Objective. Antineutrophil cytoplasmic antibodies (ANCA) are a family of antibodies that react to proteins within neutrophil granules and monocyte lysosomes, and occur prominently in sera from patients with systemic necrotizing vasculitis. The cytoplasmic staining pattern (c-ANCA) is very sensitive and specific for Wegener's granulomatosis (WG), and most commonly results from reactivity with proteinase 3 (PR3). The features of tissue damage in the fungal infection chromomycosis, in particular polymorphonuclear neutrophil (PMN) infiltration and granuloma formation, bear a resemblance to that seen in WG. Methods. We tested sera from 25 patients with clinical and histologic diagnosis of chromomycosis for the presence of ANCA by indirect immunofluorescence. These same sera were analyzed for reactivity to neutrophil primary granule extracts and PR3 by ELISA. Results. Five of the 25 patients (20%) had detectable c-ANCA, without central accentuation, at serum dilutions of at least 1:40. Three of these 5 ANCA-positive patients reacted with neutrophil primary granule extracts by ELISA; however, none of them reacted with PR3. Conclusions. These results demonstrate that fungal infection should be included among the conditions, unrelated to necrotizing vasculitis, that can trigger autoreactivity against myeloid lysosomal antigens.

Original languageEnglish (US)
Pages (from-to)479-483
Number of pages5
JournalClinical and Experimental Rheumatology
Volume14
Issue number5
StatePublished - Sep 1996

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Chromoblastomycosis
Antineutrophil Cytoplasmic Antibodies
Myeloblastin
Granulomatosis with Polyangiitis
Neutrophils
Mycoses
Serum
Enzyme-Linked Immunosorbent Assay
Systemic Vasculitis
Neutrophil Infiltration
Indirect Fluorescent Antibody Technique
Vasculitis
Lysosomes
Granuloma
Monocytes
Staining and Labeling
Antigens
Antibodies
Proteins

Keywords

  • ANCA
  • chromomycosis
  • Wegener's granulomatosis

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

Galperin, C., Shoenfeld, Y., Gilburd, B., Esterre, P., Meroni, R. L., Del Papa, N., ... Gershwin, M. E. (1996). Anti-neutrophil cytoplasmic antibodies in patients with chromomycosis. Clinical and Experimental Rheumatology, 14(5), 479-483.

Anti-neutrophil cytoplasmic antibodies in patients with chromomycosis. / Galperin, C.; Shoenfeld, Y.; Gilburd, B.; Esterre, P.; Meroni, R. L.; Del Papa, N.; Halpern, G. M.; Andriantsimahavandy, A.; Gershwin, M. Eric.

In: Clinical and Experimental Rheumatology, Vol. 14, No. 5, 09.1996, p. 479-483.

Research output: Contribution to journalArticle

Galperin, C, Shoenfeld, Y, Gilburd, B, Esterre, P, Meroni, RL, Del Papa, N, Halpern, GM, Andriantsimahavandy, A & Gershwin, ME 1996, 'Anti-neutrophil cytoplasmic antibodies in patients with chromomycosis', Clinical and Experimental Rheumatology, vol. 14, no. 5, pp. 479-483.
Galperin C, Shoenfeld Y, Gilburd B, Esterre P, Meroni RL, Del Papa N et al. Anti-neutrophil cytoplasmic antibodies in patients with chromomycosis. Clinical and Experimental Rheumatology. 1996 Sep;14(5):479-483.
Galperin, C. ; Shoenfeld, Y. ; Gilburd, B. ; Esterre, P. ; Meroni, R. L. ; Del Papa, N. ; Halpern, G. M. ; Andriantsimahavandy, A. ; Gershwin, M. Eric. / Anti-neutrophil cytoplasmic antibodies in patients with chromomycosis. In: Clinical and Experimental Rheumatology. 1996 ; Vol. 14, No. 5. pp. 479-483.
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AU - Gilburd, B.

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AU - Meroni, R. L.

AU - Del Papa, N.

AU - Halpern, G. M.

AU - Andriantsimahavandy, A.

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N2 - Objective. Antineutrophil cytoplasmic antibodies (ANCA) are a family of antibodies that react to proteins within neutrophil granules and monocyte lysosomes, and occur prominently in sera from patients with systemic necrotizing vasculitis. The cytoplasmic staining pattern (c-ANCA) is very sensitive and specific for Wegener's granulomatosis (WG), and most commonly results from reactivity with proteinase 3 (PR3). The features of tissue damage in the fungal infection chromomycosis, in particular polymorphonuclear neutrophil (PMN) infiltration and granuloma formation, bear a resemblance to that seen in WG. Methods. We tested sera from 25 patients with clinical and histologic diagnosis of chromomycosis for the presence of ANCA by indirect immunofluorescence. These same sera were analyzed for reactivity to neutrophil primary granule extracts and PR3 by ELISA. Results. Five of the 25 patients (20%) had detectable c-ANCA, without central accentuation, at serum dilutions of at least 1:40. Three of these 5 ANCA-positive patients reacted with neutrophil primary granule extracts by ELISA; however, none of them reacted with PR3. Conclusions. These results demonstrate that fungal infection should be included among the conditions, unrelated to necrotizing vasculitis, that can trigger autoreactivity against myeloid lysosomal antigens.

AB - Objective. Antineutrophil cytoplasmic antibodies (ANCA) are a family of antibodies that react to proteins within neutrophil granules and monocyte lysosomes, and occur prominently in sera from patients with systemic necrotizing vasculitis. The cytoplasmic staining pattern (c-ANCA) is very sensitive and specific for Wegener's granulomatosis (WG), and most commonly results from reactivity with proteinase 3 (PR3). The features of tissue damage in the fungal infection chromomycosis, in particular polymorphonuclear neutrophil (PMN) infiltration and granuloma formation, bear a resemblance to that seen in WG. Methods. We tested sera from 25 patients with clinical and histologic diagnosis of chromomycosis for the presence of ANCA by indirect immunofluorescence. These same sera were analyzed for reactivity to neutrophil primary granule extracts and PR3 by ELISA. Results. Five of the 25 patients (20%) had detectable c-ANCA, without central accentuation, at serum dilutions of at least 1:40. Three of these 5 ANCA-positive patients reacted with neutrophil primary granule extracts by ELISA; however, none of them reacted with PR3. Conclusions. These results demonstrate that fungal infection should be included among the conditions, unrelated to necrotizing vasculitis, that can trigger autoreactivity against myeloid lysosomal antigens.

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