Anti-monomeric c-reactive protein antibody ameliorates arthritis and nephritis in mice

Chitose Fujita, Yasuo Sakurai, Yuki Yasuda, Yoshikazu Takada, Cheng Long Huang, Masaaki Fujita

Research output: Contribution to journalArticlepeer-review

Abstract

Conformation-specific Ags are ideal targets for mAb-based immunotherapy. Here, we demonstrate that the monomeric form of C-reactive protein (mCRP) is a specific therapeutic target for arthritis and nephritis in a murine model. Screening of >1800 antimCRP mAb clones identified 3C as a clone recognizing the monomeric, but not polymeric, form of CRP. The anti-mCRP mAb suppressed leukocyte infiltration in thioglycollate-induced peritonitis, attenuated rheumatoid arthritis symptoms in collagen Abinduced arthritis model mice, and attenuated lupus nephritis symptoms in MRL/Mp-lpr/lpr lupus-prone model mice. These data suggest that the anti-mCRP mAb 3C has therapeutic potential against rheumatoid arthritis and lupus nephritis.

Original languageEnglish (US)
Pages (from-to)1755-1762
Number of pages8
JournalJournal of Immunology
Volume207
Issue number7
DOIs
StatePublished - Oct 1 2021

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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