Anti-Mitochondrial Antibody-Negative Primary Biliary Cirrhosis

Carlo Selmi, Massimo Zuin, Christopher Bowlus, M. Eric Gershwin

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The recent development in the authors' laboratory of a sensitive bead assay able to detect AMA in 20% of otherwise AMA-negative sera seems to support the hypothesis that many AMA-negative cases of primary biliary cirrhosis (PCB) are secondary to limits in the methods used and do not represent an independent clinical entity. Clinical data demonstrate that patients without detectable serum AMA do not differ in their natural history from their seropositive counterparts. Anti-nuclear antibodies have been associated repeatedly with more severe disease and are helpful tools in the management of patients who have PBC, particularly those lacking AMA.

Original languageEnglish (US)
Pages (from-to)173-185
Number of pages13
JournalClinics in Liver Disease
Volume12
Issue number1
DOIs
StatePublished - Feb 2008

Fingerprint

Biliary Liver Cirrhosis
Anti-Idiotypic Antibodies
Polychlorinated Biphenyls
Natural History
Serum

ASJC Scopus subject areas

  • Hepatology

Cite this

Anti-Mitochondrial Antibody-Negative Primary Biliary Cirrhosis. / Selmi, Carlo; Zuin, Massimo; Bowlus, Christopher; Gershwin, M. Eric.

In: Clinics in Liver Disease, Vol. 12, No. 1, 02.2008, p. 173-185.

Research output: Contribution to journalArticle

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