Anti-mda-5 negative, anti-ku positive clinically amyopathic dermatomyositis

Alexis E. Carrington, Danielle M. Tartar, Raja K. Sivamani

Research output: Contribution to journalArticlepeer-review


We present a patient with anti-MDA5 negative, anti- Ku positive clinically amyopathic dermatomyositis (CADM). A 61-year-old woman presented with a chief complaint of a 20-year history of a pruritic rash that was active on her face, chest, hands, legs, and back. A mildly scaly, erythematous, photo-distributed eruption along with slightly violaceous, scaly papules accentuated on the wrist, metacarpophalangeal joints, proximal interphalangeal and distal interphalangeal joints. Antibody profile was significant for positive ANA and anti-dsDNA, elevated anti-TIF-1gamma (RDL)/p155, and weakly positive anti Ku. Biopsy was consistent with dermatomyositis. Melanoma differentiation-associated gene 5 antibody (anti-MDA-5) has been identified as the most commonly associated autoantibody found in CADM and is associated with poor prognosis and a biomarker for the diagnosis of rapidly progressive interstitial lung disease. To our knowledge, our patient is the first case of negative anti-MDA-5 and anti-Ku positive CADM.

Original languageEnglish (US)
Article numberA6
JournalDermatology online journal
Issue number4
StatePublished - 2021


  • Antibodies
  • Autoimmune disorder
  • Dermatomyositis

ASJC Scopus subject areas

  • Dermatology


Dive into the research topics of 'Anti-mda-5 negative, anti-ku positive clinically amyopathic dermatomyositis'. Together they form a unique fingerprint.

Cite this