Anti-Müllerian hormone and ovarian aging in mares

Renata C. Uliani, Alan J Conley, C. Jo Corbin, Aimê M. Friso, Luciana F.S. Maciel, Marco A. Alvarenga

Research output: Contribution to journalArticle

Abstract

Anti-Müllerian hormone (AMH) is used as a marker of follicle population numbers and potential fertility in several species including horses but limited data exist across the lifespan. No one has decreased ovarian reserve experimentally to investigate whether a corresponding, quantitative decrease in AMH results. Concentrations of AMH across the lifespan were compiled from 1101 equine females sampled from birth to >33 years of age. Young and old mares (averaging 6 and 19 years) were hemi-ovariectomized and circulating AMH was assessed before and daily thereafter for 15 days. The remaining ovary was removed later and blood was drawn again before and after this second surgery for AMH determination. Polynomial regression analysis and analysis of mares grouped by 5-year intervals of age demonstrated AMH concentrations to be higher in mares aged 5–10 and 10–15 years than 0–5 years of age and lower in mares after 20 years of age. There was high variability in AMH concentrations among neonatal fillies, some of which had concentrations typical of males. Hemi-ovariectomy was followed by a decrease of AMH, almost exactly halving concentrations in intact mares. Concentrations of AMH had returned to intact levels in old mares before complete ovariectomy, as if exhibiting ovarian compensatory hypertrophy, but recovery of AMH was not evident in young mares. AMH may reflect ovarian senescence in mares after 20 years of age but is too variable to do so in the first two decades of life. The ovarian endocrine response to hemi-ovariectomy in mares appears to change with age.

LanguageEnglish (US)
Pages147-156
Number of pages10
JournalJournal of Endocrinology
Volume240
Issue number2
DOIs
StatePublished - Feb 1 2019

Fingerprint

Anti-Mullerian Hormone
Ovariectomy
Horses
Hypertrophy
Fertility
Ovary

Keywords

  • Aging
  • Anti-Müllerian hormone
  • Equine
  • Key Words ovary
  • Ovarian reserve

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Uliani, R. C., Conley, A. J., Jo Corbin, C., Friso, A. M., Maciel, L. F. S., & Alvarenga, M. A. (2019). Anti-Müllerian hormone and ovarian aging in mares. Journal of Endocrinology, 240(2), 147-156. https://doi.org/10.1530/JOE-18-0391

Anti-Müllerian hormone and ovarian aging in mares. / Uliani, Renata C.; Conley, Alan J; Jo Corbin, C.; Friso, Aimê M.; Maciel, Luciana F.S.; Alvarenga, Marco A.

In: Journal of Endocrinology, Vol. 240, No. 2, 01.02.2019, p. 147-156.

Research output: Contribution to journalArticle

Uliani, RC, Conley, AJ, Jo Corbin, C, Friso, AM, Maciel, LFS & Alvarenga, MA 2019, 'Anti-Müllerian hormone and ovarian aging in mares', Journal of Endocrinology, vol. 240, no. 2, pp. 147-156. https://doi.org/10.1530/JOE-18-0391
Uliani RC, Conley AJ, Jo Corbin C, Friso AM, Maciel LFS, Alvarenga MA. Anti-Müllerian hormone and ovarian aging in mares. Journal of Endocrinology. 2019 Feb 1;240(2):147-156. https://doi.org/10.1530/JOE-18-0391
Uliani, Renata C. ; Conley, Alan J ; Jo Corbin, C. ; Friso, Aimê M. ; Maciel, Luciana F.S. ; Alvarenga, Marco A. / Anti-Müllerian hormone and ovarian aging in mares. In: Journal of Endocrinology. 2019 ; Vol. 240, No. 2. pp. 147-156.
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